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Title: Synthesis and mass spectral fragmentation patterns of some thiazole and imidazolidine derivatives
Authors: Mohamed, S M
Unis, M
El-Hady, H Abd
Keywords: Synthesis
mass spectral
thiazole and imidazolidine derivatives
Issue Date: Jun-2006
Publisher: CSIR
Series/Report no.: <b>Int.Cl.<sup>8</sup> C07D</b>
Abstract: 3-[(Thiophen-2-ylmethylene)-amino]-4-oxo-imidazolidin-2-thione <b>4</b> and 5-aryl-2-[(thiophen-2-ylmethylene)-hydra­zino]-thiazole <b>5</b> have been prepared <i>via</i> cyclization of 1-(thiophen-2-ylmethylene)-thiosemicarbazone <b>3</b> with ethyl chloroacetate and ω-bromomethyl aryl ketones in presence of fused sodium acetate. Reaction of compounds <b>4 </b>and <b>5</b> with hydrazine hydrate and acetic anhydride gives 1,2-bis-(thiophen-2-ylmethylene)-hydrazone <b>7</b> and N-acetyl derivatives <b>6 </b>and<b> 10</b>. Treatment of <b>4</b> with benzyl chloride, choloracetyl chloride and 4-chlorobenzaldehyde yields the corresponding N-benzyl derivative <b>8</b>, imidazolo [5, 1-c]-oxazine <b>9</b> and 3-[(thiophen-2-ylmethylene)-amino]-4-oxo-5-(4-chlorobenzylidene)-imidazolidin-2-thione<b> 11</b>, respectively. The mass spectral fragmentation patterns of some prepared compounds have been investigated in order to elucidate the structure of the synthesized compounds.
Description: 1453-1462
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(06) [June 2006]

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