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Title: Synthesis and mass spectral fragmentation patterns of some thiazole and imidazolidine derivatives
Authors: Mohamed, S M
Unis, M
El-Hady, H Abd
Keywords: Synthesis;mass spectral;thiazole and imidazolidine derivatives
Issue Date: Jun-2006
Publisher: CSIR
IPC Code: Int.Cl.8 C07D
Abstract: 3-[(Thiophen-2-ylmethylene)-amino]-4-oxo-imidazolidin-2-thione 4 and 5-aryl-2-[(thiophen-2-ylmethylene)-hydra­zino]-thiazole 5 have been prepared via cyclization of 1-(thiophen-2-ylmethylene)-thiosemicarbazone 3 with ethyl chloroacetate and ω-bromomethyl aryl ketones in presence of fused sodium acetate. Reaction of compounds 4 and 5 with hydrazine hydrate and acetic anhydride gives 1,2-bis-(thiophen-2-ylmethylene)-hydrazone 7 and N-acetyl derivatives 6 and 10. Treatment of 4 with benzyl chloride, choloracetyl chloride and 4-chlorobenzaldehyde yields the corresponding N-benzyl derivative 8, imidazolo [5, 1-c]-oxazine 9 and 3-[(thiophen-2-ylmethylene)-amino]-4-oxo-5-(4-chlorobenzylidene)-imidazolidin-2-thione 11, respectively. The mass spectral fragmentation patterns of some prepared compounds have been investigated in order to elucidate the structure of the synthesized compounds.
Page(s): 1453-1462
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(06) [June 2006]

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