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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.45B [2006] >
IJC-B Vol.45B(06) [June 2006] >
| Title: | Synthesis and mass spectral fragmentation patterns of some thiazole and imidazolidine derivatives |
| Authors: | Mohamed, S M
Unis, M
El-Hady, H Abd |
| Keywords: | Synthesis
mass spectral
thiazole and imidazolidine derivatives |
| Issue Date: | Jun-2006 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.8 C07D |
| Abstract: | 3-[(Thiophen-2-ylmethylene)-amino]-4-oxo-imidazolidin-2-thione
4 and 5-aryl-2-[(thiophen-2-ylmethylene)-hydrazino]-thiazole 5
have been prepared via cyclization of
1-(thiophen-2-ylmethylene)-thiosemicarbazone 3 with ethyl chloroacetate
and ω-bromomethyl aryl ketones in presence of fused sodium
acetate. Reaction of compounds 4 and 5 with hydrazine hydrate and
acetic anhydride gives 1,2-bis-(thiophen-2-ylmethylene)-hydrazone 7 and
N-acetyl derivatives 6 and 10. Treatment of 4 with benzyl
chloride, choloracetyl chloride and 4-chlorobenzaldehyde yields the
corresponding N-benzyl derivative 8, imidazolo [5, 1-c]-oxazine 9
and 3-[(thiophen-2-ylmethylene)-amino]-4-oxo-5-(4-chlorobenzylidene)-imidazolidin-2-thione
11, respectively. The mass spectral fragmentation patterns of some prepared
compounds have been investigated in order to elucidate the structure of the
synthesized compounds. |
| Page(s): | 1453-1462 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.45B(06) [June 2006]
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