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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.45B [2006] >
IJC-B Vol.45B(06) [June 2006] >
| Title: | Stereochemistry of N5‑acyltetrahydro‑1,5‑benzodiazepines – NMR spectra and semiempirical MO calculations |
| Authors: | Venkatraj, M
Jeyaraman, R
Ponnuswamy, S |
| Keywords: | N5‑Acyltetrahydro-1,5-benzodiazepine
N5‑formyl
N5‑acetyl
N5‑acetyl
N5‑benzoyl
NMR spectra
Semiempirical MO calculation
boat conformation
exo-orientation
X‑ray crystal structure |
| Issue Date: | Jun-2006 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.8 C07D |
| Abstract: | The conformational preferences of N5‑acyltetrahydro-1,5-benzodiazepines 3-5 have been studied using NMR spectral techniques and semiempirical MO calculations (AM1 and PM3 methods). The N5‑formyl‑, N5‑acetyl‑ and N5‑benzoyltetrahydro‑2‑methyl‑2,4‑diphenyl ‑1H-1,5 benzodiazepines 3-5 prefer boat conformations BE with exo orientation of the acyl groups at N5. The X‑ray crystal structure of N5‑acetyl derivative 4 also shows a boat conformation BE with exo orientation of acetyl group at N5. The results obtained from semiempirical MO calculations (AM1 and PM3) are in excellent agreement with the results obtained from solution and solid states. |
| Page(s): | 1531-1540 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.45B(06) [June 2006]
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