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Title: Synthesis of some 1,3,4-oxadiazole derivatives as potential anti-inflammatory agents
Authors: Amir, Mohd
Javed, S A
Kumar, Harish
Keywords: 1,3,4-Oxadiazoles;1,2,4-Triazine-5-one;Anti-inflammatory;Ulcerogenicity;Lipid peroxidation;Ibuprofen
Issue Date: Jun-2007
Publisher: CSIR
Abstract: The synthesis of some new 1,3,4-oxadiazole derivatives and 1,2,4-triazine-5-one has been described. IR, ¹H NMR and mass spectral data support the structures of newly synthesized compounds. All the compounds have been tested in vivo for their anti-inflammatory activity by carrageenin-induced rat paw edema method. The compounds, which show good anti-inflammatory activity, have been screened for their ulcerogenic and lipid peroxidation activities.
Page(s): 1014-1019
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.46B(06) [June 2007]

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