Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/6447
Title: Synthesis and antibacterial screening of <i style="">N</i>-[Naphtho[1,2-<i>b</i>]pyrano[3,4-<i>d</i>]thiazol-8-yl] spiroindoloazetidin-2-ones/thiazolidin-4-ones
Authors: Suryavanshi, Jitendra P
Pai, Nandini R
Keywords: Naphthopyrans
azetidin-2-ones
thiazolidin-4-ones
2-oxo-1<i>H</i>-indole
antibacterial activity
Issue Date: May-2006
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>8</sup> C 07 D</b>
Abstract: 2-Amino-11-hydronaphtho[2,1:5,6]pyrano[4,3-<i style="">d</i>]thiazole <b style="">1a-d</b> on treatment with isatin affords naphtho[1,2-<i style="">b</i>]pyrano[3,4-<i style="">d</i>]thiazolo-8-yl(3-imino-2-oxo-1<i>H</i>-indole <b style="">2a-d</b> which on further reaction with chloroacetyl chloride and mercaptoacetic acid yields the corresponding <i style="">N</i>-[naphtho[1,2-<i style="">b</i>]pyrano[3,4-<i style="">d</i>]thiazol-8-yl]spiro-[3<i style="">H</i>-indole-(1<i style="">H</i>,2<i style="">H</i>)-3,4-(2<i style="">H</i>)-3-chloroazetidin-2,2-diones <b style="">3a-d</b> and <i style="">N</i>-[naphtho[1,2-<i style="">b</i>]pyrano[3,4-<i style="">d</i>]thiazol-8-yl]spiro-[3<i style="">H</i>-indole-(1<i style="">H</i>,2<i style="">H</i>)-3,2-(4<i style="">H</i>)-thiazolidine]-2,4-dione <b style="">4a-d</b>. All the compounds <b style="">2a-d</b>, <b style="">3a-d</b> and <b style="">4a-d</b> have been screened and found to possess considerable antibacterial activity.
Description: 1227-1230
URI: http://hdl.handle.net/123456789/6447
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(05) [May 2006]

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