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Title: Synthesis and antibacterial screening of N-[Naphtho[1,2-b]pyrano[3,4-d]thiazol-8-yl] spiroindoloazetidin-2-ones/thiazolidin-4-ones
Authors: Suryavanshi, Jitendra P
Pai, Nandini R
Keywords: Naphthopyrans
antibacterial activity
Issue Date: May-2006
Publisher: CSIR
IPC CodeInt.Cl.8 C 07 D
Abstract: 2-Amino-11-hydronaphtho[2,1:5,6]pyrano[4,3-d]thiazole 1a-d on treatment with isatin affords naphtho[1,2-b]pyrano[3,4-d]thiazolo-8-yl(3-imino-2-oxo-1H-indole 2a-d which on further reaction with chloroacetyl chloride and mercaptoacetic acid yields the corresponding N-[naphtho[1,2-b]pyrano[3,4-d]thiazol-8-yl]spiro-[3H-indole-(1H,2H)-3,4-(2H)-3-chloroazetidin-2,2-diones 3a-d and N-[naphtho[1,2-b]pyrano[3,4-d]thiazol-8-yl]spiro-[3H-indole-(1H,2H)-3,2-(4H)-thiazolidine]-2,4-dione 4a-d. All the compounds 2a-d, 3a-d and 4a-d have been screened and found to possess considerable antibacterial activity.
Page(s): 1227-1230
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.45B(05) [May 2006]

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