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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(04) [April 2006] >
| Title: | Effect of plantain banana on gastric ulceration in NIDDM rats: Role of gastric mucosal glycoproteins, cell proliferation, antioxidants and free radicals |
| Authors: | Kumar, M Mohan
Joshi, M C
Prabha, T
Dorababu, M
Goel, R K |
| Keywords: | Antioxidants
Cell proliferation
Free radicals
Glycoproteins
Musa sapientum
NIDDM |
| Issue Date: | Apr-2006 |
| Publisher: | CSIR |
| Abstract: | Methanolic extract of Musa sapientum var. Paradisiaca
(MSE, 100 mg/kg) was studied for its antiulcer and mucosal defensive factors in
normal and non-insulin dependent diabetes mellitus (NIDDM) rats. NIDDM was
induced by administering streptozotocin (STZ, 70 mg/kg, ip) to 5 days old rat
pups. The animals showing blood glucose level > 140mg/dL after 12 weeks of
STZ administration were considered as NIDDM positive. Effects of MSE were
compared with known ulcer protective drug, sucralfate (SFT, 500 mg/kg) and
anti-diabetic drug glibenclamide (GLC, 0.6 mg/kg) when administered orally,
once daily for 6 days against gastric ulcers (GU) induced by cold-restraint
stress (CRS) and ethanol and subsequent changes in gastric mucosal
glycoproteins, cell proliferation, free radicals (lipid peroxidation and nitric
oxide) and anti-oxidants enzymes (super oxide dismutase and catalase) and
glutathione (GSH) levels. MSE showed better ulcer protective effect in NIDDM
rats compared with SFT and GLC in CRS-induced GU. NIDDM caused a significant
decrease in gastric mucosal glycoprotein level without having any effect on
cell proliferation. However, all the test drugs reversed the decrease in
glycoprotein level in NIDDM rats, but cell proliferation was enhanced in case
of MSE alone. Both CRS or NIDDM as such enhanced gastric mucosal LPO, NO and
SOD, but decreased CAT levels while CRS plus NIDDM rats caused further increase
in LPO and NO level without causing any further changes in SOD and CAT level.
MSE pretreatment showed reversal in the levels of all the above parameters
better than GLC. Ethanol caused a decrease in glutathione level which was
further reduced in NIDDM-ethanol rats. MSE reversed the above changes
significantly in both normal as well as in NIDDM rats, while GLC reversed it
only in NIDDM rats. However, SFT was ineffective in reversing the changes
induced by CRS or ethanol or when given in NIDDM-CRS or NIDDM-ethanol rats. The
results indicated that the ulcer protective effect of MSE could be due to its
predominant effect on mucosal glycoprotein, cell proliferation, free radicals
and antioxidant systems. |
| Page(s): | 292-299 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(04) [April 2006]
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