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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(04) [April 2006] >
| Title: | Hepatoprotective activity of Psidium guajava Linn. leaf extract |
| Authors: | Roy, Chanchal K
Kamath, Jagadish V
Asad, Mohammed |
| Keywords: | Carbon tetrachloride
Hepatoprotection
Paracetamol
Psidium guajava
Thioacetamide |
| Issue Date: | Apr-2006 |
| Publisher: | CSIR |
| Abstract: | The study was designed to evaluate the
hepatoprotective activity of P. guajava
in acute experimental liver injury induced by carbon tetrachloride, paracetamol
or thioacetamide and chronic liver damage induced by carbon tetrachloride. The
effects observed were compared with a known hepatoprotective agent, silymarin.
In the acute liver damage induced by different hepatotoxins, P. guajava leaf extracts (250 and
500mg/kg, po) significantly reduced the elevated serum levels of aspartate
aminotransferase, alanine aminotransferase, alkaline phosphatase and bilirubin.
The higher dose of the extract
(500 mg/kg, po) prevented the increase in liver weight when compared to
hepatoxin treated control, while the lower dose was ineffective except in the
paracetamol induced liver damage. In the chronic liver injury induced by carbon
tetrachloride, the higher dose (500 mg/kg, po) of P. guajava leaf extract was found to be more effective than the
lower dose (250 mg/kg, po). Histological examination of the liver tissues
supported the hepatoprotection. It is concluded that the aqueous extract of
leaves of guava plant possesses good hepatoprotective activity. |
| Page(s): | 305-311 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(04) [April 2006]
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