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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(04) [April 2006] >
| Title: | Antidiabetic, antihypercholesterolaemic and antioxidant effect of Ocimum sanctum (Linn) seed oil |
| Authors: | Gupta, Shweta
Mediratta, Pramod K
Singh, Surender
Sharma, K K
Shukla, Rimi |
| Keywords: | Antioxidant activity
Hypocholesterolaemic agents
Ocimum sanctum
Seed oil |
| Issue Date: | Apr-2006 |
| Publisher: | CSIR |
| Abstract: | Antihyperlipidaemic
and antioxidant effect of Ocimum sanctum
Linn. seed oil (OSSO) was investigated in rabbits. Administration of OSSO (0.8
g/kg body weight/day) for four weeks, in cholesterol (100 mg/kg body
weight/day) fed rabbits significantly decreased serum cholesterol,
triacylglycerol and LDL-+VLDL-cholesterol as compared to untreated cholesterol
fed group. There was significant fall in atherogenic index in OSSO treated
group. In addition, treatment with OSSO decreased lipid peroxidation and
increased reduced glutathione content in blood. Antidiabetic effect of O. sanctum seed oil was evaluated in
alloxan diabetic rabbits. Two weeks treatment of diabetic rabbits with OSSO
(0.8 gm/kg/day) showed no significant hypoglycaemic effect. Results of the
present study show that OSSO has hypocholesterolaemic and antioxidant effects
but it does not have antidiabetic effect. |
| Page(s): | 300-304 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(04) [April 2006]
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