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http://nopr.niscair.res.in/handle/123456789/6419
Title: | Occurrence of non-protein low molecular weight cardiotoxin in Indian King Cobra (Ophiophagus hannah) Cantor 1836, venom |
Authors: | Saha, Archita Gomes, Aparna Giri, B Chakravarty, A K Biswas, A K Dasgupta, S C Gomes, A |
Keywords: | Cardiotoxin;Indian King Cobra;Non-protein toxin;Ophiophagus hannah;Snake venom |
Issue Date: | Apr-2006 |
Publisher: | CSIR |
Abstract: | Pathophysiology due
to snakebite is a combined effect of various actions of the complex venom
constituents. Importance of protein toxins in snake envenomation is well known.
The present investigation reports the existence of non-protein/nonpetide low
molecular weight toxin in Indian King Cobra venom, which plays an important
role in envenomation consequences in experimental animal models. A group of
non-peptidic toxins (OH-NPT1) was isolated from Indian King Cobra Ophiophagus hannah by thin layer
chromatography and silica gel column chromatography. UV, IR, NMR and (ESI) TOF-MS studies
characterized the OH-NPT1 as a mixture of aliphatic acids having molecular
weights 256, 326 and 340Da. The
minimum lethal dose of OH-NPT1 was found to be 2.5 ![]() ![]() |
Page(s): | 279-285 |
URI: | http://hdl.handle.net/123456789/6419 |
ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
Appears in Collections: | IJEB Vol.44(04) [April 2006] |
Files in This Item:
File | Description | Size | Format | |
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IJEB 44(4) 279-285.pdf | 100.14 kB | Adobe PDF | View/Open |
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