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Title: Immunotoxicity of phosphamidon following subchronic exposure in albino rats
Authors: Suke, Sanvidhan G
Ahmed, Rafat S
Tripathi, A K
Chakraborti, Ayanabha
Banerjee, B D
Keywords: Cell-mediated immunity
Humoral immunity
Issue Date: Apr-2006
Publisher: CSIR
Abstract: Effect of subchronic doses of phosphamidon exposure on humoral and cell mediated immune (CMI) responses were studied in male albino rats using SRBC, ovalbumin and KLH as antigens. Humoral immune responses were assessed by estimating antibody titre against antigen and splenic plaque forming cells (PFC) assay. CMI responses were studied by using leucocyte migration inhibition (LMI), macrophage migration inhibition (MMI) and delayed type hypersensitivity (DTH) response. Results obtained in the present study revealed marked suppression of humoral and CMI responses in a dose dependent pattern. Hence, suppression of immune responses by phosphamidon even at subchronic doses is clearly an important aspect for its safety evaluation.
Description: 316-320
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.44(04) [April 2006]

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