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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(04) [April 2006] >
| Title: | Protective effect of melatonin against propoxur-induced oxidative stress and suppression of humoral immune response in rats |
| Authors: | Suke, Sanvidhan G
Kumar, Achint
Ahmed, Rafat S
Chakraborti, Ayanabha
Tripathi, A K
Mediratta, P K
Banerjee, B D |
| Keywords: | Carbamate
Humoral immunity
Immunotoxicity
Lipid peroxidation
Pesticide |
| Issue Date: | Apr-2006 |
| Publisher: | CSIR |
| Abstract: | Effect of melatonin in attenuation of
propoxur induced oxidative stress and suppression of humoral immune response
was studied in rats. Oral administration of propoxur (10 mg/kg) increased lipid
peroxidation in serum after 28 days treatment. Superoxide dismutase, catalase
and glutathione were also altered following propoxur exposure. In addition
propoxur exposure markedly suppressed humoral immune response as assessed by
antibody titre and plaque forming cell assay. Simultaneous treatment with
melatonin (5 mg/kg, ip) markedly attenuated the effect of propoxur on (a) lipid
peroxidation, (b) oxidative stress parameters and (c) immunotoxicity. Results
have been discussed in the light of possible immunopotentiating and antioxidant
effects of melatonin to understand the influence of oxidative stress on
propoxur induced immunomodulation. |
| Page(s): | 312-315 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(04) [April 2006]
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