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IJC-B Vol.45B(03) [March 2006] >


Title: Synthesis of 1,5-benzothiazepines: Part XXX-Synthesis and antimicrobial studies of 10-substituted-6a, 7-dihydro-6H -7-(4-fluorophenyl)-6-phenyl [1] benzopyrano [3,4-c] [1,5] benzothiazepines
Authors: Pant, Umesh C
Chandra, Hem
Goyal, Shweta
Sharma, Priyanka
Pant, Seema
Keywords: 1,5-Benzothiazepines
bioactivity
fluorinated heterocycles
Issue Date: Mar-2006
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 D
Abstract:  Flavindogenide, 3-(4-fluorobenzylidene)-flavanone has been reacted with six 5-substituted-2-aminobenzenethiols, the substituents being halogens as fluoro, chloro bromo, alkyl as methyl and alkoxyl as methoxyl and ethoxyl, to obtain a series of six new compounds, 10-substituted-6a,7-dihydro-6H-7-(4-fluorophenyl)-6-phenyl[1] benzopyrano[3,4-c][1,5]benzo¬≠thiazepines 3a-f. The products are characterized on the basis of microanalytical data for elements and IR,1H NMR, 19F NMR and mass spectral studies. All the synthesized compounds have been evaluated for their antimicrobial activity against the bacteria Escherichia coli and GFC (Alteromonas tetraodonis - a new Gram-negative bacteria family) and fungi, Aspergillus niger, A. flavus and Curvularia lunata. All the compounds showed equal/greater bactericidal activity but for 3d showing lesser activity against E. coli and 3e against GFC.
Page(s): 752-757
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.45B(03) [March 2006]

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