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Title: Synthesis of 1,5-benzothiazepines: Part XXX-Synthesis and antimicrobial studies of 10-substituted-6a, 7-dihydro-6<i>H </i>-7-(4-fluorophenyl)-6-phenyl [1] benzopyrano [3,4-<i>c</i>] [1,5] benzothiazepines
Authors: Pant, Umesh C
Chandra, Hem
Goyal, Shweta
Sharma, Priyanka
Pant, Seema
Keywords: 1,5-Benzothiazepines
fluorinated heterocycles
Issue Date: Mar-2006
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D</b>
Abstract: <smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="country-region" downloadurl=""><smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="place" downloadurl=""> Flavindogenide, 3-(4-fluorobenzylidene)-flavanone has been reacted with six 5-substituted-2-aminobenzenethiols, the substituents being halogens as fluoro, chloro bromo, alkyl as methyl and alkoxyl as methoxyl and ethoxyl, to obtain a series of six new compounds, 10-substituted-6a,7-dihydro-6<i>H-</i>7-(4-fluorophenyl)-6-phenyl[1] benzopyrano[3,4-<i>c</i>][1,5]benzo¬≠thiazepines <b>3a-f</b>. The products are characterized on the basis of microanalytical data for elements and IR,<sup>1</sup>H NMR, <sup>19</sup>F NMR and mass spectral studies. All the synthesized compounds have been evaluated for their antimicrobial activity against the bacteria <i>Escherichia coli</i> and <i>GFC</i> <i>(Alteromonas tetraodonis - </i>a new <i>Gram-negative bacteria</i> family) and fungi<i>, Aspergillus niger, A. flavus</i> and <i>Curvularia lunata.</i> All the compounds showed equal/greater bactericidal activity but for <b style="">3d </b>showing lesser activity against <i>E. coli</i> and <b style="">3e</b> against <i>GFC</i>. </smarttagtype></smarttagtype>
Description: 752-757
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(03) [March 2006]

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