Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/6389
Title: Antimicrobial screening and synthesis of some novel benzo[<i style="">a</i>]phenothiazines and ribofuranosides
Authors: Kumar, Neeraj
Sharma, Anoop K
Garg, Reshu
Yadav, Ashok K
Keywords: 5<i style="">H</i>-benzo[<i style="">a</i>]phenothiazines
12<i style="">H</i>-benzo[<i style="">a</i>]phenothiazine thiones
ribofuranosides
spectral data
antimicrobial activity
Issue Date: Mar-2006
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D</b>
Abstract: Synthesis of 6-(4-chloro-2-methoxy-5-methylanilino/2-methoxy-5-methylanilino)-9-chloro-5<i style="">H</i>-benzo[<i style="">a</i>]phenothiazin-5-thione,12<i style="">H</i>-benzo[<i style="">a</i>] phenothiazin-5-ols, 5-acetoxy-12<i style="">H</i>-benzo[<i style="">a</i>] phenothiazines and 5-methoxy-12<i style="">H</i>-benzo­[<i style="">a</i>]­pheno­thiazines have been carried out from 6-(4-chloro-2-methoxy-5-methylanilino/2-methoxy-5-methylanilino)-9-chloro-5<i style="">H</i>-benzo[<i style="">a</i>] phenothiazin-5-ones; which have been synthesized by condensing zinc mercaptide of 2-amino-5-chloro-benzenethiol and 2-(4-chloro-2-methoxy-5-methylanilino/2-methoxy-5-methylanilino)-3-chloro-1,4-naphthoquinone. The ribofuranosides<i style=""> viz</i>, N-(2',3',5'-tri-<i style="">O</i>-benzoyl-β-d-ribofuranosyl)-6-(4-chloro-2-methoxy-5-methylanilino/2-methoxy-5-methylanilino)-9-chloro-5-acetoxy/5-methoxy-12<i style="">H</i>-benzo[<i style="">a</i>]phenothiazines have been synthesized by condensing synthe­sized heterocycles bases with (+)-β-d-ribofuranose-1-acetate-2,3,5-tribenzoate. Structural assignments have been done on the basis of elemental analysis, IR, and <sup>1</sup>H NMR. All the synthesized compounds have been screened for their antimicrobial activity.
Description: 747-751
URI: http://hdl.handle.net/123456789/6389
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(03) [March 2006]

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