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IJC-B Vol.45B(03) [March 2006] >


Title: Antimicrobial screening and synthesis of some novel benzo[a]phenothiazines and ribofuranosides
Authors: Kumar, Neeraj
Sharma, Anoop K
Garg, Reshu
Yadav, Ashok K
Keywords: 5H-benzo[a]phenothiazines
12H-benzo[a]phenothiazine thiones
ribofuranosides
spectral data
antimicrobial activity
Issue Date: Mar-2006
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 D
Abstract: Synthesis of 6-(4-chloro-2-methoxy-5-methylanilino/2-methoxy-5-methylanilino)-9-chloro-5H-benzo[a]phenothiazin-5-thione,12H-benzo[a] phenothiazin-5-ols, 5-acetoxy-12H-benzo[a] phenothiazines and 5-methoxy-12H-benzo­[a]­pheno­thiazines have been carried out from 6-(4-chloro-2-methoxy-5-methylanilino/2-methoxy-5-methylanilino)-9-chloro-5H-benzo[a] phenothiazin-5-ones; which have been synthesized by condensing zinc mercaptide of 2-amino-5-chloro-benzenethiol and 2-(4-chloro-2-methoxy-5-methylanilino/2-methoxy-5-methylanilino)-3-chloro-1,4-naphthoquinone. The ribofuranosides viz, N-(2',3',5'-tri-O-benzoyl-β-d-ribofuranosyl)-6-(4-chloro-2-methoxy-5-methylanilino/2-methoxy-5-methylanilino)-9-chloro-5-acetoxy/5-methoxy-12H-benzo[a]phenothiazines have been synthesized by condensing synthe­sized heterocycles bases with (+)-β-d-ribofuranose-1-acetate-2,3,5-tribenzoate. Structural assignments have been done on the basis of elemental analysis, IR, and 1H NMR. All the synthesized compounds have been screened for their antimicrobial activity.
Page(s): 747-751
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.45B(03) [March 2006]

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