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IJC-B Vol.45B(03) [March 2006] >


Title: Synthesis, antibacterial and surface activity of 1,2,4-triazole derivatives
Authors: El-Sayed, Refat
Keywords: Stearic acid
triazole derivatives
surface activity
antimicrobial activity
Issue Date: Mar-2006
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 D
Abstract: Sodium 1-[4-amino-5-mercapto-4H-(1,2,4)triazol-3-yl]heptadecane-1-sulfonate 2 has been used as a new precursor to synthesize some important biologically active heterocycles. Reaction of 2 with carbon disulphide in pyridine and acid chlorides yields the 1,2,4-triazole derivatives 3, 4a and 4b. Condensation of 2 with appropriate aldehydes gives 5a-c which have been cyclized by treating with thioglycollic acid to yield 6a-c. Reactions of 2 with phthalic anhydride and 4-methylbenzenesulfonyl chloride gives 7 and 8. In addition, the reaction of 2 with chloroacetaldehyde, phenacyl bromide, urea and chloroacetyl chloride yields 9, 10, 11 and 12, respectively. On the other hand, refluxing 2 with phenyl isothiocyanate gives 13 and 14. All these products have antimicrobial activity and they can be used as surface active agents.
Page(s): 738-746
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.45B(03) [March 2006]

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