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|Title:||Synthesis, antibacterial and surface activity of 1,2,4-triazole derivatives|
|Series/Report no.:||<b>Int.Cl.<sup>7</sup> C 07 D</b>|
|Abstract:||Sodium 1-[4-amino-5-mercapto-4<i>H</i>-(1,2,4)triazol-3-yl]heptadecane-1-sulfonate <b>2 </b>has been used<b> </b>as a new precursor to synthesize some important biologically active heterocycles. Reaction of <b>2</b> with carbon disulphide in pyridine and acid chlorides yields the 1,2,4-triazole derivatives <b>3</b>, <b>4a</b> and<b> 4b</b>. Condensation of <b>2</b> with appropriate aldehydes gives <b>5a-c</b> which have been cyclized by treating with thioglycollic acid to yield <b>6a-c</b>. Reactions of <b>2</b> with phthalic anhydride and 4-methylbenzenesulfonyl chloride gives <b>7</b> and <b>8</b>. In addition, the reaction of <b>2</b> with chloroacetaldehyde, phenacyl bromide, urea and chloroacetyl chloride yields <b>9</b>, <b>10</b>, <b>11</b> and <b>12</b>,<b> </b>respectively. On the other hand, refluxing <b>2</b> with phenyl isothiocyanate gives <b>13</b> and <b>14</b>. All these products have antimicrobial activity and they can be used as surface active agents.|
|Appears in Collections:||IJC-B Vol.45B(03) [March 2006]|
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