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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(03) [March 2006] >
| Title: | Inhibitory effect of cinnamoyl compounds against human malignant cell line |
| Authors: | Indap, M A
Radhika, S
Motiwale, Leena
Rao, K V K |
| Keywords: | Antitumor
Caffeic acid
Cinnamoyl compounds
Curcumin
Ferulic acid
Gallic acid
Platinum drugs |
| Issue Date: | Mar-2006 |
| Publisher: | CSIR |
| Abstract: | In the present study, anti-proliferative effects of dietary
polyphenolic compounds have been observed and demonstrated the strong
anticancer efficacy of curcumin (CMN), an active constituent of dietary spice
(turmeric) using human leukemia cancer cell line. CMN inhibited the
proliferation of K562 leukemic cells by induction of apoptosis. The current
study demonstrated synergy with combination of drug therapy, and suggested that
combination of ferulic acid and cisplatin synergistically inhibited cellular
proliferation. Cytotoxic synergy was observed independent of the sequence of
addition of two drugs to cultured cells. The synergized growth inhibitory
effect with cisplatin was probably associated with G2-M arrest in cell cycle
progression. These findings suggested that among the cinnamoyl compounds, CMN
was most potent and FER appeared to be a better modulating agent on human
malignant cell line. |
| Page(s): | 216-220 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(03) [March 2006]
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