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NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(03) [March 2006] >
| Title: | Cardioprotective effect of mangiferin on isoproterenol induced myocardial infarction in rats |
| Authors: | Prabhu, S
Jainu, Mallika
Sabitha, K E
Devi, C S Shyamala |
| Keywords: | Isoproterenol
Lipid peroxides
Mangiferin
Marker enzymes
Myocardial infarction |
| Issue Date: | Mar-2006 |
| Publisher: | CSIR |
| Abstract: | Isoproterenol (ISPH) induced myocardial
infarction was confirmed by disturbances in serum and heart tissue marker
enzymes such as lactate dehydrogenase (LDH), creatine phospho kinase (CPK),
aspartate transaminase (AST) and alanine transaminase (ALT), increased level of
lipid peroxidation and histopathological changes in the heart of ISPH
administered rats. Pretreatment with mangiferin (10 mg/100 g body weight) for
28 days was found to ameliorate the effect of ISPH-induced pathological
changes, reduced the lipid peroxide formation and retained the myocardial
marker enzyme activities at near normal level. The above results indicate the
cardioprotective effect of mangiferin against ISPH-induced myocardial
infarction in rats. |
| Page(s): | 209-215 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(03) [March 2006]
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