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IJEB Vol.44(03) [March 2006] >


Title: Cardioprotective effect of mangiferin on isoproterenol induced myocardial infarction in rats
Authors: Prabhu, S
Jainu, Mallika
Sabitha, K E
Devi, C S Shyamala
Keywords: Isoproterenol
Lipid peroxides
Mangiferin
Marker enzymes
Myocardial infarction
Issue Date: Mar-2006
Publisher: CSIR
Abstract: Isoproterenol (ISPH) induced myocardial infarction was confirmed by disturbances in serum and heart tissue marker enzymes such as lactate dehydrogenase (LDH), creatine phospho kinase (CPK), aspartate transaminase (AST) and alanine transaminase (ALT), increased level of lipid peroxidation and histopathological changes in the heart of ISPH administered rats. Pretreatment with mangiferin (10 mg/100 g body weight) for 28 days was found to ameliorate the effect of ISPH-induced pathological changes, reduced the lipid peroxide formation and retained the myocardial marker enzyme activities at near normal level. The above results indicate the cardioprotective effect of mangiferin against ISPH-induced myocardial infarction in rats.
Page(s): 209-215
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.44(03) [March 2006]

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