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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(03) [March 2006] >
| Title: | Induction and evaluation of atherosclerosis in New Zealand white rabbits |
| Authors: | Madhumathi, B G
Venkataranganna, M V
Gopumadhavan, S
Rafiq, Mohd.
Mitra, S K |
| Keywords: | Atherosclerosis
Blood and liver chemistry
Gross and histopathology
New Zealand white rabbits |
| Issue Date: | Mar-2006 |
| Publisher: | CSIR |
| Abstract: |
Atherosclerosis was experimentally induced in New Zealand
white rabbits by feeding a high cholesterol diet for 12 weeks for screening of
drugs against atherosclerosis. After 12 weeks, blood was collected from ear
vein for evaluation of total cholesterol (TC), triglyceride (TG), low density
lipoprotein (LDL) and very low density lipoprotein (VLDL) levels, then the
animals were sacrificed to collect the livers for estimation of cholesterol,
and aorta for gross and histopathological evaluations. The elevated levels of
serum and liver parameters accompanied by gross and histopathological changes
like accumulation of foam cells, atheromatous plaque formation and replacement
fibrosis supported the successful induction of atherosclerosis in New Zealand
white rabbits.
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| Page(s): | 203-208 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(03) [March 2006]
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