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Title: Induction and evaluation of atherosclerosis in New Zealand white rabbits
Authors: Madhumathi, B G
Venkataranganna, M V
Gopumadhavan, S
Rafiq, Mohd.
Mitra, S K
Keywords: Atherosclerosis;Blood and liver chemistry;Gross and histopathology;New Zealand white rabbits
Issue Date: Mar-2006
Publisher: CSIR
Abstract:  Atherosclerosis was experimentally induced in New Zealand white rabbits by feeding a high cholesterol diet for 12 weeks for screening of drugs against atherosclerosis. After 12 weeks, blood was collected from ear vein for evaluation of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels, then the animals were sacrificed to collect the livers for estimation of cholesterol, and aorta for gross and histopathological evaluations. The elevated levels of serum and liver parameters accompanied by gross and histopathological changes like accumulation of foam cells, atheromatous plaque formation and replacement fibrosis supported the successful induction of atherosclerosis in New Zealand white rabbits.
Page(s): 203-208
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.44(03) [March 2006]

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