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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(03) [March 2006] >
| Title: | Catheter related bacteremia in rats: A preliminary report on the effect of methylene blue coated catheter |
| Authors: | Peter, Augustine T
Steczko, Janusz
Ash, Stephen R
Dowell, Carol A
Wu, Ching C
Stevenson, Gregory W |
| Keywords: | Catheter
Jugular Vein
Methylene Blue
Rat |
| Issue Date: | Mar-2006 |
| Publisher: | CSIR |
| Abstract: | The safety and efficacy of
methylene blue (MB) coated indwelling jugular vein/cranial vena cava catheter
made up of polyurethane material was tested in a rat model, receiving bacterial
culture suspension of Pseudomonas
aeruginosa, and Staphylococcus aureus.
Daily blood samples were collected from the catheter and peripheral vein for
bacterial culture. The clinical parameters (rectal temperature, respiratory
rate, total white blood cell count, and loss in body weight) were not different
between the groups. All the rats became bacteremic with similar changes in the
number of colony forming units in the catheter and peripheral samples.
Histopathological lesions were not different between the groups. The findings
suggest that rats receiving MB coated catheters behaved similar to non-coated
catheters. Based on the results it can be concluded that for this type of gross
contamination, catheter coating alone may not eliminate infection/bacteremia. |
| Page(s): | 183-188 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(03) [March 2006]
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