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Title: Modulation of serum cortisol by Substance P in albino rats: Evidence of a direct effect on adrenal gland
Authors: Prasad, Anita
Naskar, Ranu
Dubey, Rakhi
Raha, Dipali
Ahmed, M Firoz
Keywords: Cortisol;Regulatory role;Substance P
Issue Date: Feb-2006
Publisher: CSIR
Abstract: Effect of prolonged administration of substance P on the plasma cortisol level in the albino rats has been investigated. An inhibitory impact on intact individuals and a stimulatory effect in pharmacologically annulled rats has been observed. It is concluded that in normal conditions substance P presumably acts as a preventive agent for any excess secretion of cortisol while during stress or disturbed HPA or RAS conditions, it stimulates the secretion of cortisol. An intraglandular modulatory role of substance P has been suggested.
Page(s): 163-164
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.44(02) [February 2006]

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