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IJEB Vol.44(02) [February 2006] >


Title: Evaluation of nootropic potential of Ocimum sanctum Linn. in mice
Authors: Joshi, Hanumanthachar
Parle, Milind
Keywords: Diazepam
Memory
Ocimum sanctum
Piracetam
Scopolamine
Issue Date: Feb-2006
Publisher: CSIR
Abstract: Dementia is one of the age related mental problems and a characteristic symptom of various neurodegenerative disorders including Alzheimer’s disease. Certain drugs like diazepam, barbiturates and alcohol disrupt learning and memory in animals and man. However, a new class of drugs known as nootropic agents is now used in situations where there is organic disorder in learning abilities. The present work was undertaken to assess the potential of O. sanctum extract as a nootropic and anti-amnesic agent in mice. Aqueous extract of dried whole plant of O. sanctum ameliorated the amnesic effect of scopolamine (0.4 mg/kg), diazepam (1 mg/kg) and aging induced memory deficits in mice. Elevated plus maze and passive avoidance paradigm served as the exteroceptive behavioral models. O. sanctum extract decreased transfer latency and increased step down latency, when compared to control (piracetam treated), scopolamine and aged groups of mice significantly. O. sanctum preparations could of beneficial in the treatment of cognitive disorders such as dementia and Alzheimer’s disease.
Page(s): 133-136
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.44(02) [February 2006]

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