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Title: Involvement of potassium channels in hypoglycemic effect of sertraline
Authors: Khanam, Razia
Pillai, K K
Keywords: Diabetes mellitus
Potassium channels
Issue Date: Feb-2006
Publisher: CSIR
Abstract: Effect of 21 days administration of sertraline (30 mg/kg, po) in streptozotocin (55 mg/kg, ip) induced diabetic and non-diabetic rats produced hypoglycemia in diabetic and non-diabetic rats. Pinacidil (1mg/kg, po), when co-administered with sertraline or glimepiride antagonized the decrease in glucose levels in diabetic rats. Pinacidil (10 <sup>-6</sup>-10<sup>-3 </sup><i style="">M</i>) produced dose dependent relaxation (EC<sub>50 </sub>-1.58×10<sup>-5</sup><i style="">M</i>). Neither sertraline nor glimepiride had any effect on the resting tension of ileum preparation. Both sertraline and glimepiride antagonized competitively the pinacidil-induced relaxation. The pA<sub>2</sub> values of sertraline and glimepiride reversal of pinacidil-induced relaxation were 5.5 and 6.2 respectively. These studies suggest the involvement of K<sup>+</sup> channels in hypoglycemic effects of sertraline.
Description: 120-122
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.44(02) [February 2006]

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