NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(02) [February 2006] >

Title: Involvement of potassium channels in hypoglycemic effect of sertraline
Authors: Khanam, Razia
Pillai, K K
Keywords: Diabetes mellitus
Potassium channels
Issue Date: Feb-2006
Publisher: CSIR
Abstract: Effect of 21 days administration of sertraline (30 mg/kg, po) in streptozotocin (55 mg/kg, ip) induced diabetic and non-diabetic rats produced hypoglycemia in diabetic and non-diabetic rats. Pinacidil (1mg/kg, po), when co-administered with sertraline or glimepiride antagonized the decrease in glucose levels in diabetic rats. Pinacidil (10 -6-10-3 M) produced dose dependent relaxation (EC50 -1.58×10-5M). Neither sertraline nor glimepiride had any effect on the resting tension of ileum preparation. Both sertraline and glimepiride antagonized competitively the pinacidil-induced relaxation. The pA2 values of sertraline and glimepiride reversal of pinacidil-induced relaxation were 5.5 and 6.2 respectively. These studies suggest the involvement of K+ channels in hypoglycemic effects of sertraline.
Page(s): 120-122
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.44(02) [February 2006]

Files in This Item:

File Description SizeFormat
IJEB 44(2) 120-122.pdf121.36 kBAdobe PDFView/Open
 Current Page Visits: 79 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 172471 since 01-Sep-2015  Last updated on 30-Jun-2016Webmaster: