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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(02) [February 2006] >
| Title: | Involvement of potassium channels in hypoglycemic effect of sertraline |
| Authors: | Khanam, Razia
Pillai, K K |
| Keywords: | Diabetes mellitus
Glimepiride
Pinacidil
Potassium channels
Sertraline |
| Issue Date: | Feb-2006 |
| Publisher: | CSIR |
| Abstract: | Effect of 21 days administration of
sertraline (30 mg/kg, po) in streptozotocin (55 mg/kg, ip) induced diabetic and
non-diabetic rats produced hypoglycemia in diabetic and non-diabetic rats.
Pinacidil (1mg/kg, po), when co-administered with sertraline or glimepiride
antagonized the decrease in glucose levels in diabetic rats. Pinacidil (10 -6-10-3
M) produced dose dependent
relaxation (EC50 -1.58×10-5M). Neither sertraline nor glimepiride
had any effect on the resting tension of ileum preparation. Both sertraline and
glimepiride antagonized competitively the pinacidil-induced relaxation. The pA2
values of sertraline and glimepiride reversal of pinacidil-induced relaxation
were 5.5 and 6.2 respectively. These studies suggest the involvement of K+
channels in hypoglycemic effects of sertraline. |
| Page(s): | 120-122 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(02) [February 2006]
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