|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(02) [February 2006] >
| Title: | Some novel approaches for radioprotection and the beneficial effect of natural products |
| Authors: | Maurya, Dharmendra K
Devasagayam, Thomas P A
Nair, Cherupally Krishnan K |
| Keywords: | Antioxidants
Ionizing radiation
Medicinal plants
Natural compounds
Novel approaches
Radioprotection
Radiotherapy |
| Issue Date: | Feb-2006 |
| Publisher: | CSIR |
| Abstract: | Due to the increased
use of ionizing radiation in various aspects of human life especially in areas
pertaining to radiotherapy of cancer, food preservation, agriculture, industry
and power generation, there is a need to develop an effective and non-toxic
radioprotector. The currently available ones have many drawbacks including high
cost, side effects and toxicity. Several novel approaches are on to locate a
potent radioprotector. These include mimics of antioxidant enzymes, nitroxides,
melatonin, growth factors, gene therapy, hyperthermia apart from natural
products. The latter has several advantages since they are non-toxic with
proven therapeutic benefits. These can be classified as natural compounds and
plant extracts; polyherbal formulations; besides natural and semi-natural
compounds of plant origin. A review of the above agents, their efficacy in
radioprotection and possible mechanisms responsible has been carried out. As
India and many Eastern countries have an enormous heritage of vast natural
dietary and time tested medicinal resources it is worth exploring the
possibility of developing efficient, economically viable and clinically
acceptable radioprotectors for human application from these resources. |
| Page(s): | 93-114 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(02) [February 2006]
|
|
