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Title: Microwave-assisted synthesis and biological activity of 3-alkyl /aryl-6- (1-chloro-3,4-dihydronaphth- 2-yl)-5,6-dihydro-s- triazolo [3,4-b] [1,3,4] thiadiazoles
Authors: Kamotra, Poonam
Gupta, Avinash K
Gupta, Rajive
Somal, P
Singh, S
Keywords: 3-Alkyl/aryl-6-(1-chloro-3,4-dihydronaphth-2-yl)-5;6-Dihydro-s-triazolo[3,4-b][1,3,4]thiadiazoles;p-TsOH;Microwave irradiation;Rate enhancement;Specific microwave effect;Biological activity
Issue Date: Jun-2007
Publisher: CSIR
Abstract: 3-Alkyl/aryl-6-(1-chloro-3,4-dihydronaphth-2-yl)- 5,6-dihydro-s-triazolo[3,4-b][1,3,4] thiadiazoles 3 have been synthesised by the condensation of 5-alkyl/aryl-4-amino-3-mercapto-1,2,4- triazoles 2 with 1-chloro-2-formyl-3,4-dihydronaphthalene 1 in presence of catalytic quantity of p-TsOH under microwave irradiation. Rate enhancement and improvement in yields, characteristics of synthesis under microwave irradiation, have been observed. The compounds synthesised have been characterised and screened for their antibacterial, antifungal, antiinflammatory and antioxidant activity.
Page(s): 980-984
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.46B(06) [June 2007]

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