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NPR Vol.8(5) [September-October 2009] >


Title: Evaluation of hepatoprotective activity of Capparis brevispina DC. stem bark
Authors: Aniyathi, M J Anju
Latha, P G
Manikili, P
Suja, S R
Shyamal, S
Shine, V J
Sini, S
Anuja, G I
Shikha, P
Vidyadharan, M K
Rajasekharan, S
Keywords: Capparis brevispina
Free radical scavenging activity
Hepatoprotection
Histopathology of liver
Paracetamol
Issue Date: Oct-2009
Publisher: CSIR
IPC CodeInt. cl.8 — A61K 36/00, A61K 129/00, A61P 1/16, A61P 39/06
Abstract: The effect of the ethanol extract of the stem bark of Capparis brevispina DC. (CB) was studied against paracetamol (overdose) induced hepatotoxicity in Wistar rats. Significant hepatoprotective effects were obtained against liver damage induced by overdose of paracetamol (Acetaminophen) as evident from decreased serum levels of glutamate pyruvate transaminase (SGPT), glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (SAKP) and bilirubin (SB) in the CB treated groups (250, 500 mg/kg), compared to the intoxicated controls. The hepatoprotective effect was further confirmed by histopathological studies of the liver, which showed improved architecture, absence of nuclear pycnosis, hepatocyte congestion and necrosis, when compared with the liver of the toxin group of animals. CB extract also showed significant free radical scavenging activity in vitro. Thus, the present study provides a scientific rationale for the traditional use of this plant in the management of liver disorders.
Page(s): 514-519
ISSN: 0975-1092(Online); 0972-592X(Print)
Source:NPR Vol.8(5) [September-October 2009]

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