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NPR Vol.8(5) [September-October 2009] >


Title: In vitro antidiarrhoeal activity and toxicity profile of Aegle marmelos Correa ex Roxb. dried fruit pulp
Authors: Joshi, P V
Patil, R H
Maheshwari, V L
Keywords: Aegle marmelos
Antidiarrhoeal activity
Bael tree
HPTLC
Oral acute toxicity
Umbelliferone
Issue Date: Oct-2009
Publisher: CSIR
IPC CodeInt. cl.8 — A61K 36/75, A61K 131/00, A61P 1/12, A61P 31/00
Abstract: The antidiarrhoeal effect of ethanolic extract of the dried fruit pulp of Aegle marmelos Correa ex Roxb. was studied on various intestinal pathogens. It showed excellent activity against Shigella boydii, S. sonnei and S. flexneri whereas the activity was found to be moderate against S. dysenteriae. The minimum inhibitory concentration against the strains of Shigella was recorded between 250 to 500μg/ml. Preliminary phytochemical tests of extract demonstrated the presence of common phytochemicals including phenols, tannins and flavonoids as major active constituents. Spectrophotometric study showed presence of a compound with overlapping spectrum with the marker standard Umbelliferone — a coumarin glycoside which was further confirmed by the TLC and HPTLC studies of the ethanolic extract. LD50 of >1250 mg/kg body weight, no change in the behaviour and physiological activity was recorded (at this dose) in the acute oral toxicity test in mice with the ethanolic extract of A. marmelos dried fruit pulp.
Page(s): 498-502
ISSN: 0975-1092(Online); 0972-592X(Print)
Source:NPR Vol.8(5) [September-October 2009]

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