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Title: <i>In vitro </i>antidiarrhoeal activity and toxicity profile of <i>Aegle</i> <i>marmelos </i>Correa ex Roxb. dried fruit pulp
Authors: Joshi, P V
Patil, R H
Maheshwari, V L
Keywords: <i>Aegle marmelos</i>
Antidiarrhoeal activity
Bael tree
Oral acute toxicity
Issue Date: Oct-2009
Publisher: CSIR
Series/Report no.: Int. cl.<sup>8</sup> — A61K 36/75, A61K 131/00, A61P 1/12, A61P 31/00
Abstract: The antidiarrhoeal effect of ethanolic extract of the dried fruit pulp of <b><i>Aegle marmelos</i></b> <b>Correa ex Roxb. </b>was studied on various intestinal pathogens. It showed excellent activity against <i>Shigella boydii, S. sonnei </i>and <i>S. flexneri </i>whereas the activity was found to be moderate against <i>S. dysenteriae</i><i>. </i>The minimum inhibitory concentration against the strains of <i>Shigella</i> was recorded between 250 to 500μg/ml. Preliminary phytochemical tests of extract demonstrated the presence of common phytochemicals including phenols, tannins and flavonoids as major active constituents. Spectrophotometric study showed presence of a compound with overlapping spectrum with the marker standard Umbelliferone — a coumarin glycoside which was further confirmed by the TLC and HPTLC studies of the ethanolic extract. LD<sub>50</sub> of >1250 mg/kg body weight, no change in the behaviour and physiological activity was recorded (at this dose) in the acute oral toxicity test in mice with the ethanolic extract of <b><i>A. marmelos </i></b>dried fruit pulp<i>.</i>
Description: 498-502
ISSN: 0975-1092(Online); 0972-592X(Print)
Appears in Collections:NPR Vol.8(5) [September-October 2009]

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