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NPR Vol.8(5) [September-October 2009] >


Title: In-vitro antioxidant activity of hot aqueous extract of Helicteres isora Linn. fruits
Authors: Basniwal, P K
Suthar, M
Rathore, G S
Gupta, R
Kumar, V
Pareek, A
Jain, D
Keywords: Helicteres isora
Indian Screw Tree
Total flavonoids
Superoxide
Antioxidant
Issue Date: Oct-2009
Publisher: CSIR
IPC CodeInt. cl.8—A61K 36/00, A61P 39/06.
Abstract: The antioxidant activity of the aqueous (hot) extract of Helicteres isora Linn. (AEHI) (Family—Sterculiaceae) fruits was investigated in various in vitro models. The total polyphenolic content of the extract was found 7.04% of AEHI, when compared to gallic acid and total flavonoids content was 2.4 mg/g of AEHI, when compared to rutin. Hydrogen peroxide radicals were inhibited at IC50 =165 g/ml, while ascorbic acid inhibited at 187.33 g/ml. AEHI inhibited the nitric oxide radical at IC50 = 820 g/ml, when it was compared with rutin as standard antioxidant with IC50 = 68.52 g/ml. Superoxide (SO) radical’s inhibition was compared with quercetin and IC50 value was found more than 1000 g/ml. Moreover, the results were observed in a concentration dependent manner. Present in vitro studies clearly indicated that the aqueous (hot) extract of H. isora has significant antioxidant activity.
Page(s): 483-487
ISSN: 0975-1092(Online); 0972-592X(Print)
Source:NPR Vol.8(5) [September-October 2009]

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