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Title: Hypoglycaemic effect of <i>Ficus arnottiana </i>Miq. bark extracts on streptozotocin induced diabetes in rats
Authors: Mazumder, Papiya Mitra
Farswan, Mamta
Parcha, V
Keywords: Blood glucose
<i>Ficus arnottiana</i>
<i>Paras Pipal</i>
Issue Date: Oct-2009
Publisher: CSIR
Series/Report no.: Int. cl.<sup>8</sup>—A61K 36/60
Abstract: Different species of the genus <b><i>Ficus </i></b><b>Linn. </b>such as <b><i>F. bengalensis </i></b><b>Linn.</b>, <b><i>F. glomerata </i></b><b>Roxb. </b>and <b><i>F. cunia </i></b><b>Buch.-Ham. </b>have been studied for their antidiabetic potential and used in folklore system of medicine for diabetes. In the present study, the effect of different extracts of <b><i>F. arnottiana </i></b><b>Miq. </b>bark was evaluated on fasting and posts prandial blood sugar in normal and non-insulin dependent diabetes mellitus (NIDDM) rats. Diabetes was induced by streptozotocin in neonates. Oral administration of petroleum ether, chloroform, acetone and methanol extracts of the bark (100 mg/kg, p.o.) for 21 days caused a decrease in fasting blood sugar (FBS) in diabetic rats. Among all the extracts, acetone extract was found to lower the FBS significantly (<i>P</i><0.001) in diabetic rats. Acetone extract also caused a significant decrease (<i>P</i><0.01) in post prandial blood sugar level in diabetic rats. Results of the test were compared with the standard antidiabetic drug glibenclamide (5mg/kg, p.o). Thus the present study indicates that the acetone extract of <b><i>F. arnottiana </i></b>possess antidiabetic potential.
Description: 478-482
ISSN: 0975-1092(Online); 0972-592X(Print)
Appears in Collections:NPR Vol.8(5) [September-October 2009]

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