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|Title:||Hypoglycaemic effect of Ficus arnottiana Miq. bark extracts on streptozotocin induced diabetes in rats|
|Authors:||Mazumder, Papiya Mitra|
|Keywords:||Blood glucose;Diabetes;Ficus arnottiana;Paras Pipal;Streptozotocin|
|IPC Code:||Int. cl.8—A61K 36/60|
|Abstract:||Different species of the genus Ficus Linn. such as F. bengalensis Linn., F. glomerata Roxb. and F. cunia Buch.-Ham. have been studied for their antidiabetic potential and used in folklore system of medicine for diabetes. In the present study, the effect of different extracts of F. arnottiana Miq. bark was evaluated on fasting and posts prandial blood sugar in normal and non-insulin dependent diabetes mellitus (NIDDM) rats. Diabetes was induced by streptozotocin in neonates. Oral administration of petroleum ether, chloroform, acetone and methanol extracts of the bark (100 mg/kg, p.o.) for 21 days caused a decrease in fasting blood sugar (FBS) in diabetic rats. Among all the extracts, acetone extract was found to lower the FBS significantly (P<0.001) in diabetic rats. Acetone extract also caused a significant decrease (P<0.01) in post prandial blood sugar level in diabetic rats. Results of the test were compared with the standard antidiabetic drug glibenclamide (5mg/kg, p.o). Thus the present study indicates that the acetone extract of F. arnottiana possess antidiabetic potential.|
|Appears in Collections:||NPR Vol.8(5) [September-October 2009]|
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