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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(01) [January 2006] >
| Title: | Effect of Ocimum sanctum Linn. on normal and dexamethasone suppressed wound healing |
| Authors: | Udupa, S L
Shetty, Somashekar
Udupa, A L
Somayaji, S N |
| Keywords: | Dead space wound
Dexamethasone
Excision wound
Incision wound
Ocimum sanctum
Wound healing |
| Issue Date: | Jan-2006 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 A61P |
| Abstract: | Ethanolic extract of
leaves of O. sanctum was investigated
for normal wound healing and dexamethasone depressed healing using incision,
excision and dead space wound models in albino rats. The extract of O. sanctum significantly increased the
wound breaking strength in incision wound model. The extract treated wounds
were found to epithelialize faster and the rate of wound contraction was
significantly increased as compared to control wounds. Significant increase in
wet and dry granulation tissue weight, granulation tissue breaking strength and
hydroxyproline content in dead space wound model was observed. The extract
significantly decreased the antihealing activities of dexamethasone in all the
wound models. The results indicated that the leaf extract promotes wound
healing significantly and able to overcome the wound healing suppressing action
of dexamethasone. Histological examination of granulation tissue to determine
the pattern of lay-down for collagen confirmed the results. |
| Page(s): | 49-54 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(01) [January 2006]
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