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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(01) [January 2006] >
| Title: | Effect of BR-16A (Mentat®), a polyherbal formulation on drug-induced catalepsy in mice |
| Authors: | Kumar, Anil
Kulkarni, S K |
| Keywords: | Ashwagandha
BR-16A
Catalepsy
Haloperidol
Reserpine |
| Issue Date: | Jan-2006 |
| Publisher: | CSIR |
| IPC Code: | Int Cl7 A61 P |
| Abstract: | Parkinson’s
disease (PD) is a neurodegenerative disease characterized by the selective loss
of dopamine (DA) neurons of the substantia nigra pars compacta (SNc). The
events, which trigger and/or mediate the loss of nigral DA neurons, however,
remain unclear. Neuroleptic-induced catalepsy has long been used as an animal
model for screening drugs for Parkinsonism.
Administration of haloperidol (1 mg/kg, ip) or reserpine (2 mg/kg, ip)
significantly induced catalepsy in mice. BR-16A (50 and 100 mg/kg, po), a
polyherbal formulation or ashwagandha (50 and 100 mg/kg, po), significantly
reversed the haloperidol or reserpine-induced catalepsy. The results indicate
that BR-16A or ashwagandha has protective effect against haloperidol or
reserpine-induced catalepsy and provide hope that BR-16A could be used in
preventing the drug-induced extrapyramidal side effects and may offer a new
therapeutic approach to the treatment of Parkinson's disease.
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| Page(s): | 45-48 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(01) [January 2006]
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