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IJEB Vol.44(01) [January 2006] >


Title: Effect of BR-16A (Mentat®), a polyherbal formulation on drug-induced catalepsy in mice
Authors: Kumar, Anil
Kulkarni, S K
Keywords: Ashwagandha
BR-16A
Catalepsy
Haloperidol
Reserpine
Issue Date: Jan-2006
Publisher: CSIR
IPC CodeInt Cl7 A61 P
Abstract: Parkinson’s disease (PD) is a neurodegenerative disease characterized by the selective loss of dopamine (DA) neurons of the substantia nigra pars compacta (SNc). The events, which trigger and/or mediate the loss of nigral DA neurons, however, remain unclear. Neuroleptic-induced catalepsy has long been used as an animal model for screening drugs for Parkinsonism. Administration of haloperidol (1 mg/kg, ip) or reserpine (2 mg/kg, ip) significantly induced catalepsy in mice. BR-16A (50 and 100 mg/kg, po), a polyherbal formulation or ashwagandha (50 and 100 mg/kg, po), significantly reversed the haloperidol or reserpine-induced catalepsy. The results indicate that BR-16A or ashwagandha has protective effect against haloperidol or reserpine-induced catalepsy and provide hope that BR-16A could be used in preventing the drug-induced extrapyramidal side effects and may offer a new therapeutic approach to the treatment of Parkinson's disease.
Page(s): 45-48
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.44(01) [January 2006]

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