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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.44 [2006] >
IJEB Vol.44(01) [January 2006] >
| Title: | Progesterone restores stress induced inhibition of estrous behavior in rat |
| Authors: | Madhuranath, B N
Yajurvedi, H N |
| Keywords: | Estrous behavior
Lordosis
Progesterone
Reproductive stress response |
| Issue Date: | Jan-2006 |
| Publisher: | CSIR |
| Abstract: | Exposure to a stressor (mild electrical
shocks to foot, five times per episode, at 1800, 1830, 1900 and 1930 hrs of
proestrus) coinciding with period of pre-ovulatory progesterone secretion in
rats abolished estrous behavior as shown by the absence of lordosis response and
a significant increase in rejection quotient compared to controls. These rats
did not show spermatozoa in the vaginal smear next day morning in contrast to
their presence in controls. On the other hand, rats treated with progesterone
(a single injection, 500 μg in 0.1 ml olive oil at 1800 hr of proestrus) prior
to exposure to stressor showed normal estrous behavior, as shown by
significantly lower rejection quotient than rats exposed to stress alone,
lordosis quotient similar to controls and presence of spermatozoa in the
vaginal smear next day. The results, albeit
indirectly, to the best of our knowledge, first time indicate that stress
induced impaired steroidogenesis leads to suppression of estrous behavior. |
| Page(s): | 28-31 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.44(01) [January 2006]
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