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Title: Studies on diagnostic potential of secretory antigens of Mycobacterium bovis
Authors: Trivedi, Shweta
Das, S K
Kumar, Rajesh
Chandra, Rajesh
Keywords: : Culture filtrate proteins;Delayed type hypersensitivity;Mycobacterium bovis;Purified protein derivative
Issue Date: Jan-2006
Publisher: CSIR
Abstract: Culture filtrate proteins (CFPs) of M. bovis were produced by culturing the organism for a period of 3 weeks. These CFPs elicited a good delayed hypersensitivity (DTH) reaction in cattle and guinea pig. However, CFPs showed least cross–reactivity when tested in guinea pigs sensitized with M. bovis BCG and M. phlei. CFPs were found to be well recognized by T–cells of single intradermal test (SIDT) positive cattle and were also sero-reactive. Lymphocyte transformation assay revealed the culture filtrate antigens as major T-cell antigens. CFPs induced a good interferon gamma release as compared to conventional antigen, PPD, thereby highlighting their diagnostic capabilities.
Page(s): 14-18
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.44(01) [January 2006]

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