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Title: Studies on diagnostic potential of secretory antigens of <i style="">Mycobacterium bovis</i>
Authors: Trivedi, Shweta
Das, S K
Kumar, Rajesh
Chandra, Rajesh
Keywords: : Culture filtrate proteins
Delayed type hypersensitivity
<i style="">Mycobacterium bovis</i>
Purified protein derivative
Issue Date: Jan-2006
Publisher: CSIR
Abstract: Culture filtrate proteins (CFPs) of <i style="">M. bovis</i> were produced by culturing the organism for a period of 3 weeks. These CFPs elicited a good delayed hypersensitivity (DTH) reaction in cattle and guinea pig. However, CFPs showed least cross–reactivity when tested in guinea pigs sensitized with <i style="">M. bovis </i>BCG and <i style="">M. phlei</i>. CFPs were found to be well recognized by T–cells of single intradermal test (SIDT) positive cattle and were also sero-reactive. Lymphocyte transformation assay revealed the culture filtrate antigens as major T-cell antigens. CFPs induced a good interferon gamma release as compared to conventional antigen, PPD, thereby highlighting their diagnostic capabilities.
Description: 14-18
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.44(01) [January 2006]

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