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JSIR Vol.68(11) [November 2009] >


Title: Voltammetric behaviour of an antibiotic drug and its enhancement determination in presence of cetyltrimethylammonium bromide
Authors: Jain, Rajeev
Mishra, Ritesh
Dwivedi, Ashish
Keywords: Cefpodoxime proxetil
Cetyltrimethylammonium bromide
Electrochemical study
Issue Date: Nov-2009
Publisher: CSIR
Abstract: Electrochemical behaviour of cefpodoxime proxetil (CP) at a dropping mercury electrode (DME) in presence of surfactants [cetyltrimethylammonium bromide (CTAB), sodium lauryl sulphate (SDS), Tween-20, Triton X-100] was studied by using different voltammetric techniques. Compared with DME without CTAB, reduction peak potential of CP shifts negatively and peak current is increased significantly, due to enhanced accumulation of CP with CTAB at hydrophobic electrode surface. Two well defined, cathodic and diffusion controlled waves were observed for CP in presence of CTAB in entire pH range. In electrochemical determination of CP using differential pulse polarography, presence of CTAB in absence of surfactant enhanced detection limit from 0.71 x 10-5 mol l-1 to 1.6 x 10-7 mol l-1. Analysis of CP in pharmaceutical formulations exhibited mean recoveries of 99% and 98% for both reduction peaks.
Page(s): 945-950
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Source:JSIR Vol.68(11) [November 2009]

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