Please use this identifier to cite or link to this item:
|Title:||Voltammetric behaviour of an antibiotic drug and its enhancement determination in presence of cetyltrimethylammonium bromide|
|Keywords:||Cefpodoxime proxetil;Cetyltrimethylammonium bromide;Electrochemical study|
|Abstract:||Electrochemical behaviour of cefpodoxime proxetil (CP) at a dropping mercury electrode (DME) in presence of surfactants [cetyltrimethylammonium bromide (CTAB), sodium lauryl sulphate (SDS), Tween-20, Triton X-100] was studied by using different voltammetric techniques. Compared with DME without CTAB, reduction peak potential of CP shifts negatively and peak current is increased significantly, due to enhanced accumulation of CP with CTAB at hydrophobic electrode surface. Two well defined, cathodic and diffusion controlled waves were observed for CP in presence of CTAB in entire pH range. In electrochemical determination of CP using differential pulse polarography, presence of CTAB in absence of surfactant enhanced detection limit from 0.71 x 10-5 mol l-1 to 1.6 x 10-7 mol l-1. Analysis of CP in pharmaceutical formulations exhibited mean recoveries of 99% and 98% for both reduction peaks.|
|ISSN:||0975-1084 (Online); 0022-4456 (Print)|
|Appears in Collections:||JSIR Vol.68(11) [November 2009]|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.