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Title: Synthesis of conformationally constrained ⍺-imino acid derivatives via ring-closing metathesis
Authors: Kotha, Sambasivarao
Khedkar, Priti
Keywords: Peptidomemitics;Conformationally constrained amino acids;Conformationally constrained imino acids;Ring-closing metathesis
Issue Date: Jun-2007
Publisher: CSIR
Abstract: Conformationally constrained amino acid derivatives are useful in the synthesis of peptidomimetics. Seven-, and eight-membered conformationally constrained ⍺-imino acid derivatives have been prepared via RCM (ring-closing metathesis). Interestingly, attempts to achieve the synthesis of nine-membered imino acid derivative resulted in the formation of dimeric, 18-membered macrocyclic bis-⍺-imino acid derivative.
Page(s): 975-979
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.46B(06) [June 2007]

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