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IJBB Vol.46(5) [October 2009] >


Title: Short nucleotide sequences signal spliceosomal binding in nucleic acids
Authors: Reddy, K Rupa
Mitra, Chanchal K
Keywords: Splicing sites
Alternative splicing
Short sequences
Spliceosome binding
Issue Date: Oct-2009
Publisher: CSIR
Abstract: We have explored the region around the splice sites of the human intron and exons from the exon-intron database (EID) and located a number of short 6-nucleotide and 7-nucleotide sequences that are relatively common in the regions. These short sequences, we expect play an important role in the selection of the appropriate splicing process. We propose that the external signals via short recognition sequences play the deterministic role in the actual splicing process. We have obtained 50 such sequences each from the exon and intron from the beginning and from the ending and noted a number of common features.
Page(s): 353-359
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Source:IJBB Vol.46(5) [October 2009]

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