Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/629
Title: Synthesis and antimicrobial activity of some new 2-substituted aminothiazoles
Authors: Sutariya, Bhavin
Raziy, S K
Mohan, S
Rao, S V Sambasiva
Keywords: Aminothiazoles
Schiff base
Azetidinones
Antibacterial activity
Antifungal activity
Issue Date: May-2007
Publisher: CSIR
Series/Report no.: Int.Cl.⁸ C07D
Abstract: Amino group of thiazole (SMB-1) have been treated with various aromatic aldehydes to get corresponding Schiff bases (SMB-2 to SMB-9). These Schiff bases have been then reacted with chloroacetyl chloride to get corresponding azetidinones (SMB-2a to SMB-9a). The structures of all these compounds have been established on the basis of analytical and spectral data. Compounds SMB-1, SMB-2 and SMB-6 are comparable with standard drug ampicillin against S. aureus and S. epidermidis. Compounds SMB-1, SMB-2, SMB-6 and SMB-6a are comparable with ampicillin against E. coli and K. pneumoniae. Compounds SMB-1 and SMB-6 show good activity as compared to standard drug micanazole nitrate against C. albicans and SMB-1 activity is comparable with micanazole nitrate against A. niger.
Description: 884-887
URI: http://hdl.handle.net/123456789/629
Appears in Collections:IJC-B Vol.46B(05) [May 2007]

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