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Title: Synthesis and antimicrobial activity of some new 2-substituted aminothiazoles
Authors: Sutariya, Bhavin
Raziy, S K
Mohan, S
Rao, S V Sambasiva
Keywords: Aminothiazoles;Schiff base;Azetidinones;Antibacterial activity;Antifungal activity
Issue Date: May-2007
Publisher: CSIR
IPC Code: Int.Cl.⁸ C07D
Abstract: Amino group of thiazole (SMB-1) have been treated with various aromatic aldehydes to get corresponding Schiff bases (SMB-2 to SMB-9). These Schiff bases have been then reacted with chloroacetyl chloride to get corresponding azetidinones (SMB-2a to SMB-9a). The structures of all these compounds have been established on the basis of analytical and spectral data. Compounds SMB-1, SMB-2 and SMB-6 are comparable with standard drug ampicillin against S. aureus and S. epidermidis. Compounds SMB-1, SMB-2, SMB-6 and SMB-6a are comparable with ampicillin against E. coli and K. pneumoniae. Compounds SMB-1 and SMB-6 show good activity as compared to standard drug micanazole nitrate against C. albicans and SMB-1 activity is comparable with micanazole nitrate against A. niger.
Page(s): 884-887
Appears in Collections:IJC-B Vol.46B(05) [May 2007]

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