|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.45B [2006] >
IJC-B Vol.45B(02) [February 2006] >
| Title: | Synthesis and antimicrobial evaluation of some 4- or 6-chloroisatin derivatives |
| Authors: | Pandeya, S N
Raja, A S
Nath, G |
| Keywords: | Chloroisatin-3-semicarbazones
hydrazones
6-chloroisatin
antitubercular activity
Mycobacterium tuberculosis
antibacterial activity |
| Issue Date: | Feb-2006 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D // A 61 P 31/04, 31/10 |
| Abstract: | Two series of chloroisatin-3-semicarbazones
and hydrazones have been designed and prepared by condensing 4-chloro and 6-chloroisatin
with several substituted semicarbazides and related bioisosteric hydrazides,
respectively. Investigation of in vitro antimicrobial activity of
compounds has been performed by agar double dilution method against nine
pathogenic bacteria and four pathogenic fungi. The title compounds are also
screened for their antitubercular activity against Mycobacterium
tuberculosis H37 Rv using microplate alamar blue
assay. Many of the synthesized compounds exhibit significant antibacterial
activity in comparison to sulphamethoxazole, trimethoprim and some compounds
show good antifungal activity comparable to clotrimazole. The semicarbazones
arised from the 6-chloroisatin series have exhibited good antimicrobial
activity than that obtained from 4-chloroisatins. Compounds,
6-chloroisatin-3-(2'-chlorophenyl)
semicarbazones 1b and
6-chloroisatin-3-(4'-bromophenyl)
semicarbazone 4b have shown a
promising activity in both antibacterial and antifungal screenings. None of the
compounds has been found to be active in antitubercular screening. |
| Page(s): | 494-499 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.45B(02) [February 2006]
|
|
