Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/6225
Title: Propionic acids in organic synthesis: Novel synthesis of benzimidazole, 3,1-benzoxazine, 3-aminoquinazoline and 3-aminothieno[2,3-<i>d</i>]pyrimidine derivatives containing 2-naphthyl propionyl moiety
Authors: Al-Sehemi, Abdullah G M
El-Sharief, A M Sh
Ammar, Y A
Keywords: Propionic acids
benzimidazole
benzoxazine
aminoquinazoline
aminothieno pyrimidine
naphthyl propionyl moiety
ammonium thiocyanate
sodium azide
Issue Date: Feb-2006
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D</b>
Abstract: Naproxenoyl chloride <b style="">2</b> is reacted with some nucleophilic reagents as ammonium thiocyanate and sodium azide to produce the novel isothiocyanate <b style="">3</b> and azide <b style="">4</b> derivatives, respectively. Interaction of isothiocyanate <b style="">3</b> with 1,2-phenylenediamine and anthranilic acid has produced the corresponding benzimidazole <b style="">5</b> and 3,1-benzoxazine <b style="">7</b> derivatives, respectively. Treatment of acid azide <b style="">4</b> with <i>p</i>-toluidine afforded urea derivative <b style="">9</b>. The novel quinazolinone <b style="">11</b> was synthesized by acylation of methyl anthranilate with acid chloride <b style="">2</b> followed by treatment with hydrazine hydrate.
Description: 450-455
URI: http://hdl.handle.net/123456789/6225
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(02) [February 2006]

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