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|Title:||Novel approach for the rapid and efficient synthesis of heterocyclic Schiff bases and azetidinones under microwave irradiation|
Desai, K R
|Keywords:||Schiff base;azetidinone;microwave;antibacterial activity|
|IPC Code:||Int.Cl.7 C 07 D|
|Abstract:||A series of compounds, viz. 3′′-chloro-4′′-(substituted phenyl)-1′′-[4-(coumarin-3-yl)thiazol-2-yl]-2′′-azetidinones 4a-j have been prepared by the reaction of 2-N-(substituted benzylidene)imino-4-(coumarin-3-yl)thiazoles 3a-j with chloroacetyl chloride in the presence of triethylamine. The Schiff bases 3a-j have been prepared by the condensation of 2-amino-4-(coumarin-3-yl)thiazole 1 with different aldehydes 2. Both the reactions are carried out by conventional and microwave methods. The products are screened for their antibacterial activity against Staphylococcus aureus, Bacillus subtillis, Escherichia coli and Salmonella typhi|
|Appears in Collections:||IJC-B Vol.45B(01) [January 2006]|
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