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IJC-B Vol.45B(01) [January 2006] >

Title: Novel approach for the rapid and efficient synthesis of heterocyclic Schiff bases and azetidinones under microwave irradiation
Authors: Naik, Bhanvesh
Desai, K R
Keywords: Schiff base
antibacterial activity
Issue Date: Jan-2006
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 D
Abstract: A series of compounds, viz. 3′′-chloro-4′′-(substituted phenyl)-1′′-[4-(coumarin-3-yl)thiazol-2-yl]-2′′-azetidinones 4a-j have been prepared by the reaction of 2-N-(substituted benzylidene)imino-4-(coumarin-3-yl)thiazoles 3a-j with chloroacetyl chloride in the presence of triethylamine. The Schiff bases  3a-j have been prepared by the condensation of 2-amino-4-(coumarin-3-yl)thiazole 1 with different aldehydes 2. Both the reactions are carried out by conventional and microwave methods. The products are screened for their antibacterial activity against Staphylococcus aureus, Bacillus subtillis, Escherichia coli and Salmonella typhi
Page(s): 267-271
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.45B(01) [January 2006]

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