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Title: Antioxidant and antimicrobial activity evaluation of polyhydroxycinnamic acid ester derivatives
Authors: Venkateswarlu, Somepalli
Ramachandra, Marellapudi S
Krishnaraju, Alluri V
Trimurtulu, Golakoti
Subbaraju, Gottumukkala V
Keywords: Polyhydroxycinnamates;synthesis;antioxidant;antimicrobial;SAR studies
Issue Date: Jan-2006
Publisher: CSIR
IPC Code: Int.Cl.7 C 07 C // A 61 P 31/04, 31/10
Abstract: Polyhydroxycinnamic acid esters 5a-p have been synthesized starting from the appropriately substituted benzaldehydes. The antioxidant activity of these esters has been determined by superoxide free radical scavenging activity and DPPH free radical scavenging activity. The SAR studies reveal that pyrogallol, catechol moieties are essential for good antioxidant activity and an increase in the length of alkyl chain of the ester decreases the activity. Butyl hydroxycinnamates exhibit higher antibacterial activity among the synthesized hydroxycinnamates 5a-p, but, none of these show significant antifungal activity.
Page(s): 252-257
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(01) [January 2006]

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