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IJC-B Vol.45B(01) [January 2006] >

Title: A simple synthesis of 5-spirobarbituric acids and transformations of spirocyclopropanobarbiturates to 5-substituted barbiturates
Authors: Singh, Palwinder
Paul, Kamaldeep
Keywords: Barbituric acid
C5-monosubstituted barbituric acids
Issue Date: Jan-2006
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 D
Abstract: The reactions of barbituric acid and its 1,3-dimethyl derivative with 1,2-dibromoethane, 1,4-dibromobutane, 1,5-dibromopentane and 1,2-bis[bromomethyl] benzene in DMF-K2CO3 (base), TBAHSO4 (catalyst) provide 5-spirobarbiturates as major products along with other products. The 5,7-dimethyl-5,7-diaza-spiro[2.5]octane-4,6,8-trione undergoes ring opening with -CN, -SR and Br2 to provide 5-substituted barbiturates.
Page(s): 247-251
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.45B(01) [January 2006]

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