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Title: A simple synthesis of 5-spirobarbituric acids and transformations of spirocyclopropanobarbiturates to 5-substituted barbiturates
Authors: Singh, Palwinder
Paul, Kamaldeep
Keywords: Barbituric acid
C<sub>5</sub>-monosubstituted barbituric acids
Issue Date: Jan-2006
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D</b>
Abstract: The reactions of barbituric acid and its 1,3-dimethyl derivative with 1,2-dibromoethane, 1,4-dibromobutane, 1,5-dibromopentane and 1,2-bis[bromomethyl] benzene in DMF-K<sub>2</sub>CO<sub>3</sub> (base), TBAHSO<sub>4</sub> (catalyst) provide 5-spirobarbiturates as major products along with other products. The 5,7-dimethyl-5,7-diaza-spiro[2.5]octane-4,6,8-trione undergoes ring opening with <sup>-</sup>CN, <sup>-</sup>SR and Br<sub>2</sub> to provide 5-substituted barbiturates.
Description: 247-251
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(01) [January 2006]

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