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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.45B [2006] >
IJC-B Vol.45B(01) [January 2006] >
| Title: | A simple synthesis of 5-spirobarbituric acids and transformations of spirocyclopropanobarbiturates to 5-substituted barbiturates |
| Authors: | Singh, Palwinder
Paul, Kamaldeep |
| Keywords: | Barbituric acid
dialkylation
spirobarbiturates
C5-monosubstituted barbituric acids |
| Issue Date: | Jan-2006 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D |
| Abstract: | The reactions of barbituric acid and its 1,3-dimethyl derivative with 1,2-dibromoethane, 1,4-dibromobutane, 1,5-dibromopentane and 1,2-bis[bromomethyl] benzene in DMF-K2CO3 (base), TBAHSO4 (catalyst) provide 5-spirobarbiturates as major products along with other products. The 5,7-dimethyl-5,7-diaza-spiro[2.5]octane-4,6,8-trione undergoes ring opening with -CN, -SR and Br2 to provide 5-substituted barbiturates. |
| Page(s): | 247-251 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.45B(01) [January 2006]
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