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Title: Synthesis of novel bone-targeted agents for treatment of osteoporosis
Authors: Wang, Junbo
Yang, Chunhao
Ding, Huasheng
Yan, Xueming
Wu, Xihan
Xie, Yuyuan
Keywords: Bone;osteoporosis;bisphosphonates;Raloxifene
Issue Date: Jan-2006
Publisher: CSIR
IPC Code: Int.Cl.7 C 07 D
Abstract: Novel bone-targeted agents have been designed and synthe¬≠sized by the combination of raloxifene and bisphosphonates. The anti-osteoporosis effect has been evaluated by bone mineral density (BMD) obtained from ovariectomized (OVX) mice in vivo. The results indicate that the compounds 8 and 9 not only prevent ovariectomy induced loss of bone but also enhance BMD to 7.09 and 12.59% compared to sham-operated control, respectively.
Page(s): 318-321
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(01) [January 2006]

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