Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/6180
Title: Synthesis and antimicrobial screening of 5<i style="">H</i>,7<i style="">H</i>-<i style="">N</i>-(coumarin-6-yl)-2,8-diphenyl-5,7-dioxo-4,5,6,7-tetrahydrobenzimidazo[5,6-<i style="">c</i>]­furan and 5<i style="">H</i>,7<i style="">H</i>-<i style="">N</i>-(coumarin-6-yl)-2,8-diphenyl-5,7-dioxo-6-(7-methoxy-4-methylcoumarin-6-yl)-4,5,6,7-tetrahydro benzimidazo[5,6-<i style="">c</i>]pyrrole
Authors: Choudhari, B P
Mulwad, V V
Keywords: Aminocoumarin
Schiff bases
Wittig reaction
Diel's-Alder reaction
Antimicrobial activity
Issue Date: Jan-2006
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D</b>
Abstract: The Schiff bases <b style="">2a-d</b> of 6-aminocoumarins <b style="">1a-d</b> on reaction with 4-benzylidene-2-phenyloxazolin-5-one in DMF and catalytic amount of pyridine afford 4-benzylidene-3-(coumarin-6-yl)-2-phenylimidazolin-5-ones <b style="">3a-d</b> which on further Wittig reaction yield the corresponding 4-benzylidene-3-(coumarin-6-yl)-5-methylene-2-phenylimidazolines <b style="">4a-d</b>. Compounds <b style="">4a-d</b> on Diel’s-Alder reaction with maleic anhydride and <i style="">N</i>-(7-methoxy-4-methylcoumarin-6-yl)maleimide separately give 5<i style="">H</i>,7<i style="">H</i>-<i style="">N</i>-(cou­marin-6-yl)-2,8-diphenyl-5,7-dioxo-4,5,6,7-tetrahydrobenzi­mi­d­a­zo­(5,6-<i style="">c</i>)furans <b style="">5a-d</b> and 5<i style="">H</i>,7<i style="">H</i>-<i style="">N</i>-(coumarin-6-yl)-2,8-diphenyl-5,7-dioxo-6-(7-methoxy-4-methylcoumarin-6-yl)-4,5,6,7-tetra­hydro­­benzimidazo(5,6-<i style="">c</i>)pyrroles <b style="">6a-d </b>respectively. The structures of the compounds have been established on the basis of the spectral and analytical data. All the compounds <b style="">3-6a-d </b>have been screened for their antimicrobial activities and found to exhibit significant antibacterial and antifungal activities.
Description: 314-317
URI: http://hdl.handle.net/123456789/6180
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(01) [January 2006]

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