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IJC-B Vol.45B(01) [January 2006] >


Title: Synthesis and antimicrobial screening of 5H,7H-N-(coumarin-6-yl)-2,8-diphenyl-5,7-dioxo-4,5,6,7-tetrahydrobenzimidazo[5,6-c]­furan and 5H,7H-N-(coumarin-6-yl)-2,8-diphenyl-5,7-dioxo-6-(7-methoxy-4-methylcoumarin-6-yl)-4,5,6,7-tetrahydro benzimidazo[5,6-c]pyrrole
Authors: Choudhari, B P
Mulwad, V V
Keywords: Aminocoumarin
Schiff bases
Wittig reaction
Diel's-Alder reaction
Antimicrobial activity
Issue Date: Jan-2006
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 D
Abstract: The Schiff bases 2a-d of 6-aminocoumarins 1a-d on reaction with 4-benzylidene-2-phenyloxazolin-5-one in DMF and catalytic amount of pyridine afford 4-benzylidene-3-(coumarin-6-yl)-2-phenylimidazolin-5-ones 3a-d which on further Wittig reaction yield the corresponding 4-benzylidene-3-(coumarin-6-yl)-5-methylene-2-phenylimidazolines 4a-d. Compounds 4a-d on Diel’s-Alder reaction with maleic anhydride and N-(7-methoxy-4-methylcoumarin-6-yl)maleimide separately give 5H,7H-N-(cou­marin-6-yl)-2,8-diphenyl-5,7-dioxo-4,5,6,7-tetrahydrobenzi­mi­d­a­zo­(5,6-c)furans 5a-d and 5H,7H-N-(coumarin-6-yl)-2,8-diphenyl-5,7-dioxo-6-(7-methoxy-4-methylcoumarin-6-yl)-4,5,6,7-tetra­hydro­­benzimidazo(5,6-c)pyrroles 6a-d respectively. The structures of the compounds have been established on the basis of the spectral and analytical data. All the compounds 3-6a-d have been screened for their antimicrobial activities and found to exhibit significant antibacterial and antifungal activities.
Page(s): 314-317
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.45B(01) [January 2006]

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