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|Title:||Synthesis and antimicrobial screening of 5H,7H-N-(coumarin-6-yl)-2,8-diphenyl-5,7-dioxo-4,5,6,7-tetrahydrobenzimidazo[5,6-c]furan and 5H,7H-N-(coumarin-6-yl)-2,8-diphenyl-5,7-dioxo-6-(7-methoxy-4-methylcoumarin-6-yl)-4,5,6,7-tetrahydro benzimidazo[5,6-c]pyrrole|
|Authors:||Choudhari, B P|
Mulwad, V V
|Series/Report no.:||Int.Cl.7 C 07 D|
|Abstract:||The Schiff bases 2a-d of 6-aminocoumarins 1a-d on reaction with 4-benzylidene-2-phenyloxazolin-5-one in DMF and catalytic amount of pyridine afford 4-benzylidene-3-(coumarin-6-yl)-2-phenylimidazolin-5-ones 3a-d which on further Wittig reaction yield the corresponding 4-benzylidene-3-(coumarin-6-yl)-5-methylene-2-phenylimidazolines 4a-d. Compounds 4a-d on Diel’s-Alder reaction with maleic anhydride and N-(7-methoxy-4-methylcoumarin-6-yl)maleimide separately give 5H,7H-N-(coumarin-6-yl)-2,8-diphenyl-5,7-dioxo-4,5,6,7-tetrahydrobenzimidazo(5,6-c)furans 5a-d and 5H,7H-N-(coumarin-6-yl)-2,8-diphenyl-5,7-dioxo-6-(7-methoxy-4-methylcoumarin-6-yl)-4,5,6,7-tetrahydrobenzimidazo(5,6-c)pyrroles 6a-d respectively. The structures of the compounds have been established on the basis of the spectral and analytical data. All the compounds 3-6a-d have been screened for their antimicrobial activities and found to exhibit significant antibacterial and antifungal activities.|
|Appears in Collections:||IJC-B Vol.45B(01) [January 2006]|
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