NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.45B [2006] >
IJC-B Vol.45B(01) [January 2006] >


Title: Synthesis and antimicrobial screening of 3H,11H-9-methyl-3-oxopyrano[2,3-f]cinnolino[3,4-c]pyrrazole and its derivatives
Authors: Choudhari, Bharati P
Mulwad, Vinata V
Keywords: Aminocoumarin
coupling
cyclisation
cinnolino [3,4-c]pyrrazoles
antimicrobial activity
Issue Date: Jan-2006
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 D // A 61 P 31/04, 31/10
Abstract: The coupling reaction of the diazonium salt solution of the 6-aminocoumarins 1a-c with ethylacetoacetate has afforded the corresponding hydrazones 2a-c, which on further intramolecular cyclisation with PPA yielded the corresponding 3H,7H,10H-9-acetyl-3,10-dioxopyrano[2,3-f]cinnolines 3a-c. Reaction of 3a-c with hydrazine hydrate has afforded the 3H,11H-9-methyl-3-oxopyrano[2,3-f]cinnolino[3,4-c]pyrrazoles 4a-c, which on Mannich condensation with formaldehyde and morpholine yield the corresponding 3H-9-methyl-3-oxo-11-(N-methylenemorpho­lino)pyrano[2,3-f]cinnolino[3,4-c] pyrrazoles 5a-c. The reaction of 3a-c with phenyl hydrazine and 4-methyl-7-methoxycoumarin-6-ylhydrazine hydrochloride afforded 3H-9-methyl-3-oxo-11-phenyl pyrano[2,3-f]cinnolino[3,4-c]pyrrazoles 6a-c and 3H-9-methyl-3-oxo-11-(4-methyl-7-methoxy-2-oxo-2H-[1]-benzo­py­ran-6-yl)pyrano[2,3-f]cinnolino[3,4-c]pyrrazoles 7a-c, respectively. The structures of the compounds 2-7a-c have been established on the basis of spectral and analytical data. All the above compounds have been screened for their antimicrobial activities and are found to possess significant antibacterial and antifungal activities.
Page(s): 309-313
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.45B(01) [January 2006]

Files in This Item:

File Description SizeFormat
IJCB 45B(1) 309-313.pdf122.98 kBAdobe PDFView/Open
 Current Page Visits: 409 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 511631 since 06-Feb-2009  Last updated on 21-Apr-2014Webmaster: nopr@niscair.res.in