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|Title:||New spectrophotometric methods for the estimation of Lercanidipine hydrochloride|
|Authors:||Sastry, T Manikya|
|Abstract:||Three simple and sensitive visible spectrophotometic methods (A-C) have been developed for the assay of Lercanidipine hydrochloride (LER) in bulk and formulations. Method A is based on the formation of colour species by condensation reaction of drug with vanillin (<img src='/image/spc_char/lamda.gif'><sub>max</sub>=600). Method B is based on the formation of colour species between the drug and citric acid/acetic anhydride (<img src='/image/spc_char/lamda.gif'><sub>max</sub>=555) by means of forming inner salt formation. Method C is based on the formation of colour species by charge transfer complex formation with chloranil-acetaldehyde (<img src='/image/spc_char/lamda.gif'><sub>max</sub>=585). The results of analysis have been validated statistically. Recoveries range from 99.4 to 100.5% for the routine assay of LER formulations.|
|ISSN:||0975-0991 (Online); 0971-457X (Print)|
|Appears in Collections:||IJCT Vol.16(5) [September 2009]|
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