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Title: New spectrophotometric methods for the estimation of Lercanidipine hydrochloride
Authors: Sastry, T Manikya
Ramakrishna, K
Keywords: Spectrophotometry;Lercanidipine hydrochloride;CiA/Ac2O;Vanillin;TQ-CH3CHO
Issue Date: Sep-2009
Publisher: CSIR
Abstract: Three simple and sensitive visible spectrophotometic methods (A-C) have been developed for the assay of Lercanidipine hydrochloride (LER) in bulk and formulations. Method A is based on the formation of colour species by condensation reaction of drug with vanillin (max=600). Method B is based on the formation of colour species between the drug and citric acid/acetic anhydride (max=555) by means of forming inner salt formation. Method C is based on the formation of colour species by charge transfer complex formation with chloranil-acetaldehyde (max=585). The results of analysis have been validated statistically. Recoveries range from 99.4 to 100.5% for the routine assay of LER formulations.
Page(s): 431-436
ISSN: 0975-0991 (Online); 0971-457X (Print)
Appears in Collections:IJCT Vol.16(5) [September 2009]

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