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Indian Journal of Chemical Technology (IJCT) >
IJCT Vol.16 [2009] >
IJCT Vol.16(5) [September 2009] >
| Title: | Estimation of Ibuprofen solubilization in cationic and anionic surfactant media: Application of micelle binding model |
| Authors: | Bhattamishra, S D
Padhy, R K |
| Keywords: | Micelle
Surfactant
UV Spectroscopy
Absorption
Solubility
Ibuprofen |
| Issue Date: | Sep-2009 |
| Publisher: | CSIR |
| Abstract: | Drug solubility is
an important parameter for efficient drug delivery and absorption. Ibuprofen,  -methyl-4-[2-methylpropyl] benzene acetic acid is a NSAID group of
drug with antipyretic and analgesic properties. It has poor solubility in
water. Its solubilisation properties in presence of cetyltrimethylammonium
bromide (CTAB) and sodiumdodecyl sulphate (SDS) have been studied. Saturation
solubilities in aqueous and aqueous-micellar media have been studied
spectrophotometrically by measuring absorbance at 264 nm. Plot of solubility
versus [SDS] shows a maximum in the pre-micellar region followed by the linear
relationship between the variables in the region past critical micellar
concentration (cmc). With CTAB, the solubility- [surfactant] profile shows
double maxima, one each in pre- and post- micellar region. Appropriate
explanation has been forwarded and the nature of solubilizate-surfactant
interaction suggested. The pKa
values of ibuprofen determined pH-metrically in aqueous and aqueous-SDS
media have been used to supplement the inference. The association constant
values and free energy change of solubilisation are reported. |
| Page(s): | 426-430 |
| ISSN: | 0975-0991 (Online); 0971-457X (Print) |
| Source: | IJCT Vol.16(5) [September 2009]
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