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Title: Retroviral vectors and gene therapy: An update
Authors: Maurya, S K
Srivastava, Sushant
Joshi, R K
Keywords: Gene therapy
Issue Date: Oct-2009
Publisher: CSIR
Abstract: Gene therapy aims at treatment of diseases by transfer of genetic material into specific cells of a patient. So the transduction of appropriate target cell is critical. Retroviruses infect nearly every cell in the target population and become integrated in host cell genome for a stable expression. All retroviruses have only three structural genes <i>gag, pol </i>and<i> env</i>, except for lentiviruses where two other genes <i>tat, rev </i>and four accessory genes are required (<i>vif, vpu, nif, vpr</i>). There are two components of retroviral vector system—i) Packaging cell lines, which provide the products of <i>gag, pol </i>& <i>env </i>genes but are unable to package itself as they lack the <img src='/image/spc_char/shi.gif'> sequence, and ii) retroviral vectors where <i>gag, pol </i>and <i>env</i> are deleted but <img src='/image/spc_char/shi.gif'> sequence along with LTR is present. Several other types of vectors are also described.
Description: 349-357
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Appears in Collections:IJBT Vol.08(4) [October 2009]

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