NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Biotechnology (IJBT) >
IJBT Vol.08 [2009] >
IJBT Vol.08(4) [October 2009] >

Title: Studies on microbial transformation of albendazole by soil fungi
Authors: Prasad, G Shyam
Girisham, S
Reddy, S M
Keywords: Albendazole sulfoxide
albendazole sulfone
Issue Date: Oct-2009
Publisher: CSIR
Abstract:  Soil enrichment technique was followed to isolate the fungi capable of performing biotransformation of albendazole. Among the 5 fungi isolated, Aspergillus fumigatus, A. niger and Penicillium chrysogenum could transform albendazole to one metabolite and Fusarium moniliforme could transform albendazole to two metabolites. The transformation was confirmed by HPLC. Based on LC-MS-MS analysis, the metabolites formed were predicted to be albendazole sulfoxide and albendazole sulfone. The results support that the soil enrichment is a promising technique for isolation of fungi with industrial applicability, viz. production of active metabolites from drugs.
Page(s): 425-429
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Source:IJBT Vol.08(4) [October 2009]

Files in This Item:

File Description SizeFormat
IJBT 8(4) 425-429.pdf164.24 kBAdobe PDFView/Open
 Current Page Visits: 155 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 167102 since 01-Sep-2015  Last updated on 28-Jun-2016Webmaster: