Studies on microbial transformation of albendazole by soil fungi

Abstract

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Soil enrichment technique was followed to isolate the fungi capable of performing biotransformation of albendazole. Among the 5 fungi isolated, <i style="">Aspergillus fumigatus</i>, <i style="">A. niger</i> and <i style="">Penicillium chrysogenum</i> could transform albendazole to one metabolite and <i style="">Fusarium moniliforme</i> could transform albendazole to two metabolites. The transformation was confirmed by HPLC. Based on LC-MS-MS analysis, the metabolites formed were predicted to be albendazole sulfoxide and albendazole sulfone. The results support that the soil enrichment is a promising technique for isolation of fungi with industrial applicability, viz. production of active metabolites from drugs.</smarttagtype></smarttagtype>