|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biotechnology (IJBT) >
IJBT Vol.08 [2009] >
IJBT Vol.08(4) [October 2009] >
| Title: | Studies on microbial transformation of albendazole by soil fungi |
| Authors: | Prasad, G Shyam
Girisham, S
Reddy, S M |
| Keywords: | Albendazole sulfoxide
albendazole sulfone
biotransformation
fungi |
| Issue Date: | Oct-2009 |
| Publisher: | CSIR |
| Abstract: |
Soil
enrichment technique was followed to isolate the fungi capable of performing
biotransformation of albendazole. Among the 5 fungi isolated, Aspergillus fumigatus, A. niger and Penicillium chrysogenum could transform albendazole to one
metabolite and Fusarium moniliforme
could transform albendazole to two metabolites. The transformation was
confirmed by HPLC. Based on LC-MS-MS analysis, the metabolites formed were
predicted to be albendazole sulfoxide and albendazole sulfone. The results
support that the soil enrichment is a promising technique for isolation of
fungi with industrial applicability, viz. production of active metabolites from
drugs. |
| Page(s): | 425-429 |
| ISSN: | 0975-0967 (Online); 0972-5849 (Print) |
| Source: | IJBT Vol.08(4) [October 2009]
|
|
