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Title: Studies on microbial transformation of albendazole by soil fungi
Authors: Prasad, G Shyam
Girisham, S
Reddy, S M
Keywords: Albendazole sulfoxide
albendazole sulfone
Issue Date: Oct-2009
Publisher: CSIR
Abstract: <smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="country-region"><smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="place"> Soil enrichment technique was followed to isolate the fungi capable of performing biotransformation of albendazole. Among the 5 fungi isolated, <i style="">Aspergillus fumigatus</i>, <i style="">A. niger</i> and <i style="">Penicillium chrysogenum</i> could transform albendazole to one metabolite and <i style="">Fusarium moniliforme</i> could transform albendazole to two metabolites. The transformation was confirmed by HPLC. Based on LC-MS-MS analysis, the metabolites formed were predicted to be albendazole sulfoxide and albendazole sulfone. The results support that the soil enrichment is a promising technique for isolation of fungi with industrial applicability, viz. production of active metabolites from drugs.</smarttagtype></smarttagtype>
Description: 425-429
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Appears in Collections:IJBT Vol.08(4) [October 2009]

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