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IJBT Vol.08(4) [October 2009] >


Title: Promoter region polymorphism of CYP11B2 (344 C>T) gene in healthy volunteers of South Indian Tamilian population
Authors: Rajan, S
Ramu, P
Shewade, D G
Adithan, C
Keywords: Aldosterone
blood pressure
CYP11B2
genotype
polymorphism
Issue Date: Oct-2009
Publisher: CSIR
Abstract: CYP11B2 gene encodes aldosterone synthase enzyme, which produces aldosterone. The objective of study was to establish the allele and genotype frequency of CYP11B2 (344 C>T) gene polymorphism in healthy volunteers of South Indian Tamilian population. Authors carried out the study in 424 unrelated healthy volunteers including both male and female subjects. Genotyping was done by PCR-RFLP method. The observed genotype and allele frequencies were compared with other major ethnic groups. The influence of blood pressure was also analyzed with respect to the genotypes. The allele frequency was 39.9 and 601% for wild type C allele and variant T allele, respectively. The diastolic blood pressure was found to be significantly higher in the variant TT homozygous genotypes in the total study subjects and also in the male subjects (p<0.05). Interethnic difference in the genotype and allele frequencies of CYP11B2 gene polymorphism was observed in the South Indian Tamilian population.
Page(s): 358-362
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Source:IJBT Vol.08(4) [October 2009]

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