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|Title:||Promoter region polymorphism of <i style="">CYP11B2 </i>(344 C>T) gene in healthy volunteers of South Indian Tamilian population|
Shewade, D G
|Abstract:||<i style="">CYP11B2</i> gene encodes aldosterone synthase enzyme, which produces aldosterone. The objective of study was to establish the allele and genotype frequency of <i style="">CYP11B2</i> (344 C>T) gene polymorphism in healthy volunteers of South Indian Tamilian population. Authors carried out the study in 424 unrelated healthy volunteers including both male and female subjects. Genotyping was done by PCR-RFLP method. The observed genotype and allele frequencies were compared with other major ethnic groups. The influence of blood pressure was also analyzed with respect to the genotypes. The allele frequency was 39.9 and 601% for wild type C allele and variant T allele, respectively. The diastolic blood pressure was found to be significantly higher in the variant TT homozygous genotypes in the total study subjects and also in the male subjects (<i style="">p</i><0.05). Interethnic difference in the genotype and allele frequencies of <i>CYP11B2</i> gene polymorphism was observed in the South Indian Tamilian population.|
|ISSN:||0975-0967 (Online); 0972-5849 (Print)|
|Appears in Collections:||IJBT Vol.08(4) [October 2009]|
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