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IJBT Vol.08(4) [October 2009] >


Title: In silico docking of ligand 3-hydroxy methyl xylitol with target protein ZnT-8 involved in type II diabetes
Authors: Praveena, P
Ignacimuthu, S
Keywords: In silico docking
ligand
target protein
type II diabetes
Issue Date: Oct-2009
Publisher: CSIR
Abstract: ZnT-8 protein has been localized in insulin secretory granules. An automated molecule model for the target protein ZnT-8 was generated at Swiss 3D modeling. Ramachandran plot was used to determine the angles. ADMET properties were calculated for the ligand, 3-hydroxy methyl xylitol. Pre ADMET hyperchem tool was used to find the QSAR properties of the ligand. In silico docking of ligand 3-hydroxy methyl xylitol with target protein ZnT-8 involved in type II diabetes was carried out to assess the efficacy of the ligand in binding to the target. The study indicated high affinity between the ligand and the target protein, suggesting that 3-hydroxy methyl xylitol is a good drug to control blood glucose levels
Page(s): 453-455
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Source:IJBT Vol.08(4) [October 2009]

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