NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Biotechnology (IJBT) >
IJBT Vol.08 [2009] >
IJBT Vol.08(4) [October 2009] >

Title: In silico docking of ligand 3-hydroxy methyl xylitol with target protein ZnT-8 involved in type II diabetes
Authors: Praveena, P
Ignacimuthu, S
Keywords: In silico docking
target protein
type II diabetes
Issue Date: Oct-2009
Publisher: CSIR
Abstract: ZnT-8 protein has been localized in insulin secretory granules. An automated molecule model for the target protein ZnT-8 was generated at Swiss 3D modeling. Ramachandran plot was used to determine the angles. ADMET properties were calculated for the ligand, 3-hydroxy methyl xylitol. Pre ADMET hyperchem tool was used to find the QSAR properties of the ligand. In silico docking of ligand 3-hydroxy methyl xylitol with target protein ZnT-8 involved in type II diabetes was carried out to assess the efficacy of the ligand in binding to the target. The study indicated high affinity between the ligand and the target protein, suggesting that 3-hydroxy methyl xylitol is a good drug to control blood glucose levels
Page(s): 453-455
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Source:IJBT Vol.08(4) [October 2009]

Files in This Item:

File Description SizeFormat
IJBT 8(4) 453-455.pdf725.3 kBAdobe PDFView/Open
 Current Page Visits: 99 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 168412 since 01-Sep-2015  Last updated on 29-Jun-2016Webmaster: