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|Title:||<i style="">In silico</i> docking of ligand 3-hydroxy methyl xylitol with target protein ZnT-8 involved in type II diabetes|
|Keywords:||In silico docking|
type II diabetes
|Abstract:||ZnT-8 protein has been localized in insulin secretory granules. An automated molecule model for the target protein ZnT-8 was generated at Swiss 3D modeling. Ramachandran plot was used to determine the angles. ADMET properties were calculated for the ligand, 3-hydroxy methyl xylitol. Pre ADMET hyperchem tool was used to find the QSAR properties of the ligand. <i style="">In</i> <i>silico</i> docking of ligand 3-hydroxy methyl xylitol with target protein ZnT-8 involved in type II diabetes was carried out to assess the efficacy of the ligand in binding to the target. The study indicated high affinity between the ligand and the target protein, suggesting that 3-hydroxy methyl xylitol is a good drug to control blood glucose levels|
|ISSN:||0975-0967 (Online); 0972-5849 (Print)|
|Appears in Collections:||IJBT Vol.08(4) [October 2009]|
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