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http://nopr.niscair.res.in/handle/123456789/6117| Title: | A convenient synthesis of 2(2-benzo[b]furo)indoles and benzofuropyrazoles |
| Authors: | Goudarshivannanavar, B C Jayadevappa, H Mahadevan, K M |
| Keywords: | 2-Acetylbenzofuran;phenylhydrazine hydrochloride;zinc chloride;Fisher indole synthesis;Vilsmeier-Haack reaction |
| Issue Date: | Oct-2009 |
| Publisher: | CSIR |
| Abstract: | A short synthesis of benzo[b]furo indolyls 3a-g from 2-acetylbenzofuran 1 in two steps and corresponding pyrazoles 4a-g is described. An interesting scale-up procedure for the synthesis of 2-acetylbenzofuran is also been reported. Similarly 2-acetylbenzofurohydrazones 2a-g is prepared from 2-acetyl benzofuran and with various phenylhydrazine hydrochlorides in presence of CH3COONa/EtOH at RT in excellent yield (90-95%). These 2-acetyl benzofurohydrazones 2a-g are subjected to Fischer indole cyclisation in presence of ZnCl2 in acetonitrile as solvent to get 2(2-benzo[b]furo)indoles 3a-g in good yield. |
| Page(s): | 1419-1423 |
| URI: | http://hdl.handle.net/123456789/6117 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.48B(10) [October 2009] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 48B(10) 1419-1423.pdf | 49.96 kB | Adobe PDF | View/Open |
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