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IJC-B Vol.48B(10) [October 2009] >


Title: Synthesis, antimicrobial and antitubercular activity of some cyclohexenone and indazole derivatives
Authors: Vyas, D H
Tala, S D
Akbari, J D
Dhaduk, M F
Joshi, H S
Keywords: Cyclohexenones
indazoles
antimicrobial activity
antitubercular activity
Issue Date: Oct-2009
Publisher: CSIR
Abstract: The series of compounds 6-carbethoxy-5-aryl-3-(3,5-dibromo-4-methoxy phenyl)-2-cyclohexenones 2a-j are obtained from the (2E)-1-(3,5-dibromo-4-methoxyphenyl)-3-aryl-prop-2-en-1-ones 1a-j by Michael addition of ethyl acetoacetate, followed by internal Claisen condensation. Reaction of 2a-j with hydrazine hydrate afforded the corresponding 6-(3,5-dibromo-4-methoxyphenyl)-4-aryl-2,3a,4,5-tetrahydro-3H-indazol-3-ones 3a-j. The constitution of all the synthesized compounds have been established by elemental analyses, IR, 1H NMR and mass spectral data. All the compounds have been screened for their antimicrobial activities and compounds 2a-j have been tested for antitubercular activity.
Page(s): 1405-1410
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.48B(10) [October 2009]

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