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Title: Synthesis, antimicrobial and antitubercular activity of some cyclohexenone and indazole derivatives
Authors: Vyas, D H
Tala, S D
Akbari, J D
Dhaduk, M F
Joshi, H S
Keywords: Cyclohexenones
antimicrobial activity
antitubercular activity
Issue Date: Oct-2009
Publisher: CSIR
Abstract: The series of compounds 6-carbethoxy-5-aryl-3-(3,5-dibromo-4-methoxy phenyl)-2-cyclohexenones <b style="">2a-j</b> are obtained from the (<i style="">2E</i>)-1-(3,5-dibromo-4-methoxyphenyl)-3-aryl-prop-2-en-1-ones <b style="">1a-j</b> by Michael addition of ethyl acetoacetate, followed by internal Claisen condensation. Reaction of <b style="">2a-j</b> with hydrazine hydrate afforded the corresponding 6-(3,5-dibromo-4-methoxyphenyl)-4-aryl-2,3a,4,5-tetrahydro-3<i style="">H</i>-indazol-3-ones <b style="">3a-j</b>. The constitution of all the synthesized compounds have been established by elemental analyses, IR, <sup>1</sup>H NMR and mass spectral data. All the compounds have been screened for their antimicrobial activities and compounds <b style="">2a-j</b> have been tested for antitubercular activity.
Description: 1405-1410
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.48B(10) [October 2009]

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